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首页> 美国卫生研究院文献>British Journal of Clinical Pharmacology >A comparison of the effects of aspirin on bleeding time measured using the Simplate™ method and closure time measured using the PFA-100™ in healthy volunteers
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A comparison of the effects of aspirin on bleeding time measured using the Simplate™ method and closure time measured using the PFA-100™ in healthy volunteers

机译：在健康志愿者中比较使用阿司匹林对使用Simplate™方法测量的出血时间和使用PFA-100™测量的闭合时间的影响

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> Aims The aim of this study was to compare the effects of aspirin on platelet function as measured by the ‘classical’ template bleeding time with a new ex vivo method measuring closure times using the PFA-100™ machine. Platelet aggregation in response to arachidonic acid was also measured ex vivo. > Methods The trial was a randomized, double-blind, placebo-controlled crossover design, with each volunteer taking 750 mg aspirin (BP) or placebo, three times a day for 5 days, with an 18 day wash-out period between treatments. Bleeding times and closure times were measured before the first dose on the first day and 0.5 h after the last dose on the fifth day of each treatment period. They were also measured 2 weeks after the last day of the trial. > Results Baseline bleeding times (pre-placebo) were 415 s using the Simplate, whilst baseline closure times were 115 s using the PFA-100™. Aspirin treatment caused an increase of both the template bleeding time (61%) and the closure time of the PFA-100™ (79%) when compared with the effects of placebo. The platelet aggregatory response to arachidonic acid was completely inhibited following aspirin treatment and was unaffected following placebo. Two weeks after the end of the trial, all values had returned to pre-treatment levels. The template bleeding time was unaltered in 1 of the 12 volunteers during aspirin treatment and was significantly prolonged in 3 of the 12 volunteers during placebo treatment. The PFA-100™ closure time was unaltered in 1 of the 12 volunteers during aspirin treatment and was prolonged in 1 subject during placebo treatment. > Conclusions The change in closure time using the PFA-100™ is as sensitive and reproducible to the effects of aspirin on platelet function as is the template bleeding time test. However, the PFA-100™ produced less variable effects with fewer false positive results.
机译：> 目的：本研究的目的是比较阿司匹林对血小板功能的影响，该作用通过“经典”模板出血时间与使用PFA-100测量闭合时间的新型离体方法进行比较。 ™机器。还离体测量了响应花生四烯酸的血小板聚集。 > 方法：该试验是一项随机，双盲，安慰剂对照的交叉设计，每名志愿者服用750mg阿司匹林（BP）或安慰剂，每天3次，共5天，并洗18天两次治疗之间的间隔期。在每个治疗周期的第一天，在第一剂给药前和在最后一剂药后0.5 h，测量出血时间和闭合时间。在试验的最后一天两周后也进行了测量。 > 结果：使用Simplate基线出血时间（安慰剂前）为415µs，而使用PFA-100 ™基线闭合时间为115µs。与安慰剂相比，阿司匹林治疗可增加模板出血时间（61％）和PFA-100 ™的闭合时间（79％）。阿司匹林治疗后对花生四烯酸的血小板聚集反应被完全抑制，而安慰剂后则不受影响。试验结束两周后，所有数值均恢复至治疗前水平。阿司匹林治疗期间12名志愿者中的1名模板出血时间未改变，而安慰剂治疗期间12名志愿者中的3名模板出血时间显着延长。阿司匹林治疗期间12名志愿者中有1名的PFA-100 ™闭合时间未改变，安慰剂治疗期间1名受试者的PFA-100 ™闭合时间未改变。 > 结论：使用PFA-100 ™改变闭合时间与模板出血时间测试一样，对阿司匹林对血小板功能的影响同样敏感且可重现。但是，PFA-100 ™产生的可变效应较少，假阳性结果较少。

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