• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>The British Journal of Ophthalmology >Retinal and preretinal localisation of epidermal growth factor transforming growth factor alpha and their receptor in proliferative diabetic retinopathy.
【2h】

Retinal and preretinal localisation of epidermal growth factor transforming growth factor alpha and their receptor in proliferative diabetic retinopathy.

机译：表皮生长因子转化生长因子α及其受体在增生性糖尿病视网膜病变中的视网膜和视网膜前定位。

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A number of growth factors have been implicated in the development and perpetuation of preretinal fibrovascular membranes in patients with proliferative diabetic retinopathy (PDR). The aim of this study was to determine the potential role of epidermal growth factor (EGF), transforming growth factor alpha (TGF-alpha), and their receptor (EGF-R) in PDR development. Immunostaining for EGF, TGF-alpha, and EGF-R was compared between normal retina, PDR retina, and PDR preretinal membranes. Weak staining for EGF and EGF-R was observed throughout the neural retina from non-diabetic eyes while weak to moderate staining for TGF-alpha was observed in the ganglion cell layer and the inner and outer nuclear layers. In contrast, intense staining for EGF and TGF-alpha and moderate staining for EGF-R were observed throughout the PDR retina. Immunoreactivity for EGF, TGF-alpha, and EGF-R was seen in the majority of the 11 excised membranes studied and, though variable, was generally greater than that observed in normal retinas. These results suggest an autocrine/paracrine role for EGF, TGF-alpha, and EGF-R in PDR.
机译：糖尿病性增生性视网膜病变（PDR）患者的视网膜前纤维血管膜的发育和永存涉及许多生长因子。这项研究的目的是确定表皮生长因子（EGF），转化生长因子α（TGF-alpha）及其受体（EGF-R）在PDR发育中的潜在作用。在正常视网膜，PDR视网膜和PDR视网膜前膜之间比较了EGF，TGF-α和EGF-R的免疫染色。从非糖尿病眼的整个神经视网膜观察到EGF和EGF-R的染色较弱，而在神经节细胞层和内，外核层中观察到的TGF-α染色较弱至中等。相反，在整个PDR视网膜上均观察到EGF和TGF-α的强烈染色和EGF-R的中等染色。在所研究的11块切除的膜中，大多数都观察到了对EGF，TGF-α和EGF-R的免疫反应性，尽管可变，但通常比正常视网膜中观察到的更大。这些结果表明EDR，TGF-α和EGF-R在PDR中具有自分泌/旁分泌作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号