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首页> 美国卫生研究院文献>The British Journal of Ophthalmology >Ocular changes associated with Giardia lamblia infection in children
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Ocular changes associated with Giardia lamblia infection in children

机译：小儿贾第鞭毛虫感染相关的眼部变化

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摘要

BACKGROUND—The protozoan disease giardiasis can cause ocular complications, including "salt and pepper" retinal changes.
METHODS—Ophthalmic examinations were performed in 141 children (mean age 4.7 (SD 2.0) years) with active or past giardiasis diagnosed on the basis of microscopic examination of stool specimens or duodenal secretions—53 were newly diagnosed and untreated (group A), 50 had active infections in spite of metronidazole therapy (group B), and 38 had been successfully treated, with negative stool specimens for 1-3 years (group C). 300 children with no evidence of giardiasis were used as controls.
RESULTS—Salt and pepper retinal changes (with normal electroretinographic findings) were diagnosed in 28 (19.9%) of the patients with giardiasis (11 from group A, 10 from group B, and seven from group C), including five pairs of siblings. In all subgroups, the children with retinal changes were consistently younger than those with normal retinas. In eight cases, the lesions could be visualised only with direct ophthalmoscopy.
CONCLUSION—Our findings indicate that asymptomatic, non-progressive retinal lesions are particularly common in younger children with giardiasis. This risk does not seem to be related to the severity of the infection, its duration, or the use of metronidazole but may reflect a genetic predisposition.

Keywords: gastrointestinal disease; Giardia lamblia; eye; retina
机译：背景技术—原虫病贾第鞭毛虫病可引起眼部并发症，包括“盐和胡椒”的视网膜变化。
方法—对141例儿童进行了眼科检查（平均年龄4.7（SD 2.0）岁），诊断为活动性或过去的贾第鞭毛虫病。粪便标本或十二指肠分泌物的显微镜检查基础-新诊断和未治疗的有53例（A组），尽管使用了甲硝唑治疗仍发生了50例活动性感染（B组），并且已经成功治疗了38例，粪便标本阴性1例-3年（C组）。将300名没有贾第鞭毛虫病证据的儿童用作对照。
结果-在28名（19.9％）贾第鞭毛虫病患者中诊断出盐和胡椒的视网膜改变（视网膜电图检查正常）（A组11名，A组10名） B组，以及C组的7个），包括5对兄弟姐妹。在所有亚组中，具有视网膜变化的儿童始终比具有正常视网膜的儿童年轻。在8例病例中，只有通过直接眼底镜才能看到病变。
结论—我们的发现表明，无症状，非进行性视网膜病变在贾第鞭毛虫病的幼儿中尤为常见。这种风险似乎与感染的严重程度，持续时间或甲硝唑的使用无关，但可能反映出遗传易感性。

贾第鞭毛虫眼睛;视网膜

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