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首页> 美国卫生研究院文献>The Journal of Physiology >Physiological origins of evoked magnetic fields and extracellular field potentials produced by guinea-pig CA3 hippocampal slices
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Physiological origins of evoked magnetic fields and extracellular field potentials produced by guinea-pig CA3 hippocampal slices

机译：豚鼠CA3海马切片产生的诱发磁场和细胞外场电位的生理起源

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This study examined whether evoked magnetic fields and intra- and extracellular potentials from longitudinal CA3 slices of guinea-pig can be interpreted within a single theoretical framework that incorporates ligand- and voltage-sensitive conductances in the dendrites and soma of the pyramidal cells. The 1991 CA3 mathematical model of R. D. Traub is modified to take into account the asymmetric branching patterns of the apical and basal dendrites of the pyramidal cells. The revised model accounts for the magnitude and waveform of the bi- and triphasic magnetic fields evoked by somatic and apical stimulations, respectively, in the slice in the absence of fast inhibition (blocked by 0.1 mm picrotoxin). The revised model also accounts for selective effects of 4-aminopyridine (4-AP) and tetraethylammonium (TEA), which block the potassium channels of A and C type, respectively, on the slow wave of the magnetic fields. Furthermore, the model correctly predicts the laminar profiles of field potential as well as intracellular potentials in the pyramidal cells produced by two classes of cells - those directly activated and those indirectly (synaptically) activated by the applied external stimulus. The intracellular potentials in this validated model reveal that the spikes and slow waves of the magnetic fields are generated in or near the soma and apical dendrites, respectively. These results demonstrate that a single theoretical framework couched within the modern concepts of cellular physiology provides a unified account of magnetic fields outside the slice, extracellular potentials within the slice and intracellular potentials of the pyramidal cells for CA3.
机译：这项研究检查了是否可以在单个理论框架内解释豚鼠纵向CA3切片诱发的磁场以及细胞内和细胞外电位，该理论框架将锥体细胞的树突和体中结合了配体和电压敏感的电导。修改了1991年R. D. Traub的CA3数学模型，以考虑到锥体细胞的顶端和基底树突的不对称分支模式。修改后的模型说明了在没有快速抑制（被0.1 mm的微毒素阻断）的情况下，体细胞和心尖刺激分别诱发的双和三相磁场的大小和波形。修改后的模型还考虑了4-氨基吡啶（4-AP）和四乙基铵（TEA）的选择性作用，它们分别阻断A型和C型钾通道对磁场慢波的影响。此外，该模型正确地预测了由两类细胞产生的锥体细胞的场势以及细胞内势的层状分布-那些直接激活的细胞和那些通过外部刺激间接（突触地）激活的细胞。在这个经过验证的模型中的细胞内电势表明，在体细胞和顶端树突中或附近分别产生了磁场的尖峰和慢波。这些结果表明，细胞生理学现代概念中包含的单个理论框架提供了切片外磁场，切片内细胞外电势和锥体细胞对CA3的细胞内电势的统一解释。

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