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首页> 美国卫生研究院文献>British Journal of Cancer >Electron spin resonance study of changes during development of solid yoshida tumour. II. Paramagnetic metal ions.
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Electron spin resonance study of changes during development of solid yoshida tumour. II. Paramagnetic metal ions.

机译：电子自旋共振研究吉田实体瘤发生过程中的变化。二。顺磁性金属离子。

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摘要

Electron spin resonance (ESR) spectroscopy was used to examine changes in the concentration of paramagnetic metal ions in Yoshida tumours carried by female Wistar rats. Blood, spleen and lymph nodes from these animals were also examined by ESR. A decrease in the concentration of a paramagnetic species associated with mitochondrial activity, and marked increases in those thought to be associated with inflammatory or immune reactions and cell lysis, were observed in the tumours within one day of implantation. During development of the tumour, and during its regression after treatment with methylene dimethane sulphonate (MDMS), further changes were observed in the concentration of the species. These were dependent on the region of the tumour examined. In blood, development of the tumour produced an increase in ceruloplasmin and a decrease in iron-transferrin. An increase in spleen weight, as the tumour developed, was accompanied by a small decrease in the concentration of species with g-values of 6-0 and 4-3, which was reversed on regression of the treated tumour. The presence of metastases in the regional lymph nodes produced distinguishable changes in the ESR spectra.
机译：电子自旋共振（ESR）光谱用于检查雌性Wistar大鼠携带的吉田肿瘤中顺磁性金属离子浓度的变化。还通过ESR检查了这些动物的血液，脾脏和淋巴结。在植入后的一天之内，在肿瘤中观察到与线粒体活性有关的顺磁性物质浓度降低，而与炎症或免疫反应和细胞溶解有关的物质明显增加。在肿瘤的发展过程中，以及在用二甲基磺酸二甲酯（MDMS）处理后的消退过程中，观察到物种浓度的进一步变化。这些取决于所检查的肿瘤区域。在血液中，肿瘤的发展导致铜蓝蛋白增加，铁转铁蛋白减少。随着肿瘤的发展，脾脏重量的增加伴随着g值为6-0和4-3的物种浓度的小幅下降，这在治疗的肿瘤消退时被逆转。区域淋巴结中转移的存在在ESR光谱中产生了明显的变化。

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