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首页> 美国卫生研究院文献>British Journal of Cancer >Influence of hyperthermia on the oxygen enhancement ratio for x-rays measured in vivo.
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Influence of hyperthermia on the oxygen enhancement ratio for x-rays measured in vivo.

机译：体内温度过高对X射线增氧率的影响。

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The skin of mouse tail has been used to study the effect of hyperthermia on the oxygen enhancement ratio (OER). Heating was by immersion of a portion of the tail in hot water. Radiation was given either immediately before or after hyperthermia. The average skin reaction between 15 and 50 days after treatment was taken as the end-point. The OER in the absence of hyperthermia was 1.77, suggesting significant hypoxia of the skin. When hyperthermia was given after irradiation the measured value for the OER was not significantly different, but with prior hyperthermia the OER was increased to an average value of 2.3. This increase in OER is probably due to a transient increase in blood circulation following hyperthermia and causing improved tissue oxygenation during irradiation. As a consequence we would expect a greater thermal enhancement ratio for heat given before irradiation than afterwards, and this has frequently been observed with other normal tissues. There was no evidence that heat reduces OER, as has been reported by some authors on the basis of experiments performed on cells in vitro.
机译：老鼠尾巴的皮肤已被用于研究热疗对氧气增强比（OER）的影响。通过将一部分尾巴浸入热水中进行加热。在热疗之前或之后立即进行放射治疗。以治疗后15至50天的平均皮肤反应为终点。没有热疗的OER为1.77，表明皮肤明显缺氧。辐照后进行热疗时，OER的测量值没有显着差异，但是在先前的热疗中，OER增加到平均值为2.3。 OER的增加可能是由于热疗后血液循环的短暂增加，并导致了照射过程中组织氧合的改善。结果，我们期望在辐射之前给予的热量比之后具有更大的热增强率，这在其他正常组织中经常观察到。正如一些作者根据体外细胞实验所报道的那样，没有证据表明热量会降低OER。

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