首页> 美国卫生研究院文献>British Journal of Cancer >The relationship between histological grade oestrogen receptor status events and survival at 8 years in the NATO (Nolvadex) trial.
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The relationship between histological grade oestrogen receptor status events and survival at 8 years in the NATO (Nolvadex) trial.

机译:在NATO(Nolvadex)试验中组织学等级雌激素受体状态事件与8年生存率之间的关系。

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摘要

A pathological review was carried out on 600 patients with breast carcinoma entered into the 'Nolvadex' Adjuvant Trial Organisation (NATO) study. The tumours were graded histologically and these results were compared with the oestrogen receptor (ER) status of the tumours, the numbers of recurrences and the length of survival of the patients. It was found that histological grading was predictive both in terms of events and survival, and correlates significantly with oestrogen receptor status; within histological grades I and II, patients receiving 'Nolvadex' had fewer events and deaths compared with patients in the control group. For patients with grade III tumours qualitatively it was in the same direction as the benefit obtained in patients with grade I and II tumours.
机译:对进入“ Nolvadex”辅助试验组织(NATO)研究的600例乳腺癌患者进行了病理学检查。对肿瘤进行组织学分级,并将这些结果与肿瘤的雌激素受体(ER)状态,复发次数和患者生存时间进行比较。发现组织学分级在事件和存活方面都是可预测的,并且与雌激素受体状态显着相关。在组织学I级和II级中,与对照组相比,接受“ Nolvadex”治疗的患者事件和死亡较少。定性地,对于具有III级肿瘤的患者,其方向与具有I级和II级肿瘤的患者所获得的益处相同。

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