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首页> 美国卫生研究院文献>British Journal of Cancer >Expression of the small cell carcinoma antigens of cluster-5 and cluster-5A in primary lung tumours.
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Expression of the small cell carcinoma antigens of cluster-5 and cluster-5A in primary lung tumours.

机译：cluster-5和cluster-5A小细胞癌抗原在原发性肺肿瘤中的表达。

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摘要

The expression of the small cell carcinoma (SCLC) antigens cluster-5 (antibody LAM8) and cluster-5A (antibody SWA20) was examined on a panel of routinely processed biopsy or surgical specimens of 290 lung tumours by immunoperoxidase staining. Antigen expression was largely restricted to SCLC. Of over 150 tissue samples evaluated, moderate or strong antigen expression was found in 49% (cluster-5) and 45% (cluster-5A). Concordance in expression of the two antigens was seen in 71% of SCLC samples, with 35% expressing both antigens strongly, 8% moderately and 28% being negative for both antigens. Antigen expression was independent of the morphological subtype of SCLC. Primary lung tumours of other histology, including squamous cell carcinoma, large cell carcinoma, adenocarcinoma, mesothelioma or carcinoid had no significant antigen expression. Of 135 tumours, strong or moderate expression of both antigens was seen only in two cases. 20%, mostly carcinoids, were weakly positive for cluster 5 and 4% for cluster 5A antigen. The remainder were antigen negative. No significant antigen expression was seen in 25 normal lung tissues. The membrane antigens of SCLC cluster 5 and 5A are markers for SCLC and their expression in tissues is tumour-associated.
机译：小细胞癌（SCLC）抗原簇5（抗体LAM8）和簇5A（抗体SWA20）的表达通过免疫过氧化物酶染色在一组常规处理的290例肺肿瘤活检或手术标本上进行了检查。抗原表达主要限于SCLC。在评估的150多个组织样本中，发现中度或强抗原表达的分别为49％（簇5）和45％（簇5A）。在71％的SCLC样品中观察到两种抗原表达的一致性，其中35％强烈表达两种抗原，中度表达8％，28％均为阴性。抗原表达与SCLC的形态亚型无关。其他组织学的原发性肺肿瘤，包括鳞状细胞癌，大细胞癌，腺癌，间皮瘤或类癌，均无明显的抗原表达。在135个肿瘤中，仅在两个病例中可见到两种抗原的强或中等表达。 20％（主要是类癌）对簇5呈弱阳性，对簇5A抗原呈4％。其余均为抗原阴性。在25个正常肺组织中未观察到明显的抗原表达。 SCLC簇5和5A的膜抗原是SCLC的标记物，它们在组织中的表达与肿瘤相关。

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