Expression of the pNR-2/pS2 protein in diverse human epithelial tumours.

机译：pNR-2 / pS2蛋白在多种人类上皮肿瘤中的表达。

代理获取

本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。

页面导航

摘要
著录项
相似文献
相关主题

摘要

The pNR-2/pS2 protein is regulated by oestrogens in breast cancer cell lines. This report describes a systematic survey of pNR-2/pS2 expression in a number of common epithelial tumours. Expression was evaluated immunohistochemically in an archival series using antisera raised against the C-terminus of the pNR-2/pS2 protein. Expression of pNR-2/pS2 by malignant epithelial tumours was widespread. Intense immunohistochemical staining was found in tumour cells in a proportion of pancreatic (6/8), large intestinal (7/12), gastric (9/16) and endometrial (4/12) carcinomas. Positive staining for the pNR-2/pS2 protein was also found in both benign and malignant ovarian epithelial tumours and was very significantly associated with mucinous differentiation (P less than 0.00001). Small numbers of carcinomas of bladder (2/10) and prostate (2/7) showed less intense staining and single examples of cervical carcinoma (1/7) and lung carcinoma (1/19) stained positively. None of the renal carcinomas (0/16) examined stained positively. Positive staining showed no correlation with gender. Although there are reports of oestrogen receptor expression in most of the tumour types considered, the possibility of other regulatory influences must also be considered. The pNR-2/pS2 protein may well have a more general role in human epithelial neoplasia than hitherto realised.

机译：pNR-2 / pS2蛋白受乳腺癌细胞系中的雌激素调节。该报告描述了许多常见上皮肿瘤中pNR-2 / pS2表达的系统研究。使用针对pNR-2 / pS2蛋白C端的抗血清以档案系列进行免疫组织化学评估表达。恶性上皮肿瘤表达了pNR-2 / pS2。在肿瘤细胞中发现了强烈的免疫组化染色，比例为胰腺癌（6/8），大肠癌（7/12），胃癌（9/16）和子宫内膜癌（4/12）。在良性和恶性卵巢上皮肿瘤中也发现了pNR-2 / pS2蛋白的阳性染色，并且与粘液分化非常显着相关（P小于0.00001）。少数膀胱癌（2/10）和前列腺癌（2/7）表现出较弱的染色，宫颈癌（1/7）和肺癌（1/19）的单个样本呈阳性。检查的肾癌（0/16）均未染色阳性。阳性染色与性别无关。尽管有报道在大多数考虑的肿瘤类型中都有雌激素受体表达，但也必须考虑其他调节作用的可能性。 pNR-2 / pS2蛋白在人类上皮瘤形成中的作用可能比迄今为止认识到的更为普遍。

著录项

期刊名称 British Journal of Cancer
作者
J. A. Henry; M. K. Bennett; N. H. Piggott; D. L. Levett; F. E. May; B. R. Westley;
展开▼
作者单位

展开▼
年(卷),期 1991(64),4
年度 1991
页码 677–682
总页数 6
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词

相似文献

外文文献
中文文献
专利

1. Expression of the pNR-2/pS2 protein in diverse human epithelial tumours [J] . JA Henry, MK Bennett, NH Piggott, British Journal of Cancer . 1991,第4期

机译：pNR-2 / pS2蛋白在多种人类上皮肿瘤中的表达
2. HIGH-RESOLUTION SOLUTION STRUCTURE OF HUMAN PNR-2/PS2 - A SINGLE TREFOIL MOTIF PROTEIN [J] . Polshakov VI., Gargaro AR., Frenkiel TA., Journal of Molecular Biology . 1997,第2期

机译：人PNR-2 / PS2的高分辨率解决方案结构-单三叶草蛋白
3. Constitutive expression of DeltaN-p63alpha isoform in human thymus and thymic epithelial tumours. [J] . Chilosi M, Zamo A, Brighenti A, Virchows Archiv: an international journal of pathology . 2003,第2期

机译：DeltaN-p63alpha亚型在人胸腺和胸腺上皮肿瘤中的组成性表达。
4. Protein Expression by Human Intestinal Epithelial Cells in Response to Wastewater Constituents [C] . Hiroko Isoda, Junkyu Han, Terence P.N. Talorete, Annual Meeting of the Japanese Association for Animal Cell Technology . 2009

机译：蛋白质表达人肠上皮细胞响应废水成分
5. Regulation of muc1 expression by cytokine and progesterone receptor interplay in HES, a human uterine epithelial cell line, and expression of human MUC1 during early pregnancy in a human MUC1 transgenic mouse model. [D] . Dharmaraj, Neeraja. 2009

机译：在人类MUC1转基因小鼠模型中，通过人子宫上皮细胞系HES中细胞因子和孕激素受体相互作用对muc1表达的调节，以及人类MUC1的表达。
6. Comparative analysis of expression of the proprotein convertases furin PACE4 PC1 and PC2 in human lung tumours. [O] . M. Mbikay, F. Sirois, J. Yao, 1997

机译：人肺肿瘤中前蛋白转化酶弗林蛋白酶PACE4PC1和PC2表达的比较分析。
7. Expression of the pNR-2/pS2 protein in diverse human epithelial tumours. [O] . Henry, J. A., Bennett, M. K., Piggott, N. H., 1991

机译：pNR-2 / pS2蛋白在多种人类上皮肿瘤中的表达。

Expression of the pNR-2/pS2 protein in diverse human epithelial tumours.

摘要

著录项

相似文献

相关主题

期刊订阅