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首页> 美国卫生研究院文献>British Journal of Cancer >Experimental and clinical studies with somatostatin analogue octreotide in small cell lung cancer.
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Experimental and clinical studies with somatostatin analogue octreotide in small cell lung cancer.

机译：生长抑素类似物奥曲肽在小细胞肺癌中的实验和临床研究。

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摘要

We have detected somatostatin receptors (SSR) by autoradiography in 3/4 established small cell lung cancer (SCLC) cell lines but not in two non-SCLC cell lines. The growth of 1/3 SSR positive SCLC cell lines was significantly inhibited by the long-acting somatostatin analogue octreotide (SMS 201-995, Sandostatin) 10(-9) M. We treated 20 SCLC patients with octreotide 250 micrograms three times daily for 1 week prechemotherapy (six patients) or at relapse after chemotherapy (14). Octreotide was well tolerated, and serum insulin-like growth factor-I levels were suppressed to 62 +/- 7% of pre-treatment levels. However there was no evidence of anti-tumour activity measured by tumour bulk or serum levels of neuron-specific enolase. In one patient metastatic skin nodules were shown to be SSR positive before and at the end of 2 weeks octreotide. Despite this the patient had progressive disease, and tumour cells obtained by fine needle aspirate before and after treatment showed no growth inhibition when cultured with octreotide immediately or following establishment as a cell line. In summary we saw little correlation between SSR expression and growth inhibition by octreotide, either in vitro or clinically.
机译：我们已经通过放射自显影在3/4建立的小细胞肺癌（SCLC）细胞系中检测了生长抑素受体（SSR），但在两种非SCLC细胞系中未检测到。长效生长抑素类似物奥曲肽（SMS 201-995，Sandostatin）10（-9）M显着抑制了1/3 SSR阳性SCLC细胞系的生长。我们对20例SCLC患者使用奥曲肽250微克每天3次治疗，化疗前1周（6名患者）或化疗后复发（14）。奥曲肽耐受性良好，血清胰岛素样生长因子-I水平被抑制至治疗前水平的62 +/- 7％。然而，没有证据表明肿瘤体积或神经元特异性烯醇化酶的血清水平可测量出抗肿瘤活性。在一名患者中，在奥曲肽2周之前和结束时，转移性皮肤结节显示为SSR阳性。尽管如此，该患者仍具有进行性疾病，并且在治疗前和治疗后通过细针抽吸获得的肿瘤细胞当立即与奥曲肽一起培养或建立为细胞系后，均未显示出生长抑制作用。总之，无论在体外还是在临床上，我们都发现SSR表达与奥曲肽的生长抑制之间几乎没有相关性。

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