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首页> 美国卫生研究院文献>British Journal of Cancer >Comparative study of the influence of pregnancy and hormonal treatment on mammary carcinogenesis.
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Comparative study of the influence of pregnancy and hormonal treatment on mammary carcinogenesis.

机译：妊娠和激素治疗对乳腺癌致癌作用影响的比较研究。

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Since it has been shown that pregnancy protects the mammary gland from chemically induced carcinogenesis, this study was designed with the dual purpose of determining whether treatment of young virgin rats with the placental hormone chorionic gonadotropin (hCG) mimics pregnancy-induced changes in the tumourigenic response of the mammary gland and also whether the effect induced by both pregnancy and hormonal treatments was transitory, or a more permanent one, exerting the same effect when the period of time between delivery or termination of treatment and exposure to the carcinogen is lengthened. Virgin Sprague-Dawley rats were utilised in two experimental protocols. For protocol I, 50 day-old rats were either mated (Group II), or started receiving a daily intraperitoneal injection of 100 IU hCG (Group III) at age 50. Age-matched untreated virgin rats were used as controls (Group I). Twenty-one days after either delivery or termination of treatment all the animals received an intragastric dose of 8 mg DMBA/100 gbw. For the second protocol, 50 day-old virgin rats were also mated (Group V) or were treated with hCG for 21 days (Group VI); the resting period between delivery or termination of treatment was lengthened to 63 days, at which time they received a dose of DMBA. Age-matched controls (Group IV) received DMBA only. Tumourigenesis was evaluated 24 weeks post-carcinogen administration in all the groups. Pregnancy and hCG followed by the 21-day resting period significantly depressed mammary carcinogenesis to 11% and 6% respectively, compared with 63% in control animals. When the resting period was prolonged to 63 days there was also a significant depression in adenocarcinoma incidence to 9% in pregnancy (Group IV) in which it was observed that tumour incidence was also reduced as a consequence of aging at the time of exposure to the carcinogen. These results clearly indicate that hCG is as efficient as pregnancy and significantly reduces mammary carcinogenesis, and that the protective effect of both pregnancy and hCG treatment is long-lasting and both are more efficient than aging in reducing mammary carcinogenesis.
机译：由于已经证明妊娠可以保护乳腺免于化学诱导的致癌作用，因此本研究的双重目的是确定用胎盘激素绒毛膜促性腺激素（hCG）处理的处女幼鼠是否模仿了妊娠引起的肿瘤发生反应。乳腺的影响，以及妊娠和激素治疗所引起的效果是暂时的还是永久性的，当治疗的开始或终止以及接触致癌物之间的时间延长时，其效果相同。在两个实验方案中使用了维京Sprague-Dawley大鼠。对于方案I，将50天大的大鼠交配（组II），或在50岁时开始接受每天腹腔注射100 IU hCG（组III）。使用年龄匹配的未经治疗的处女大鼠作为对照组（组I） 。在递送或终止治疗后二十一日，所有动物接受8mg DMBA / 100gbw的胃内剂量。对于第二种方案，也将50天大的处女大鼠交配（V组）或用hCG治疗21天（VI组）；分娩或终止治疗之间的休息时间延长至63天，此时他们接受了DMBA剂量。年龄匹配的对照组（IV组）仅接受DMBA。在所有组中，在致癌剂给药后24周评估了肿瘤的发生。妊娠和hCG以及随后的21天休息期将乳癌的发生率分别显着降低至11％和6％，而对照动物中则为63％。当静息期延长至63天时，妊娠中腺癌的发生率也显着降低至9％（第IV组），其中观察到由于暴露于子宫内膜时的衰老，肿瘤的发生率也降低了。致癌物。这些结果清楚地表明，hCG与妊娠一样有效，并且显着减少了乳癌的发生，并且妊娠和hCG治疗的保护作用都是持久的，并且两者在减少乳癌的发生上都比衰老更有效。

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