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首页> 美国卫生研究院文献>British Journal of Cancer >31P nuclear magnetic resonance spectroscopy histology and cytokinetics of a xenografted hypopharynx carcinoma following treatment with cisplatin: comparison in three sublines with increasing resistance.
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31P nuclear magnetic resonance spectroscopy histology and cytokinetics of a xenografted hypopharynx carcinoma following treatment with cisplatin: comparison in three sublines with increasing resistance.

机译：顺铂治疗后的异种移植下咽癌的31P核磁共振波谱组织学和细胞动力学：在耐药性增加的三个亚系中进行比较。

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摘要

The changes in the phosphorus metabolism of a xenografted hypopharynx carcinoma (Hyp 1), sensitive to cisplatin (CDDP), were compared to those occurring in two sublines of the tumour, characterised by moderate or high resistance to CDDP (Hyp 1/H and Hyp 1/R) following, i.p. administration of 4, 8 or 12 mg CDDP/kg-1. The investigations were performed by in vivo 31P nuclear magnetic resonance (NMR) spectroscopy. Parallel to the NMR experiments, the cytokinetic and histological alterations in the tumours were studied under the same experimental conditions. No mentionable differences in the levels of the main phosphorus-containing metabolites could be detected between the three tumour lines before treatment. Following application of CDDP, the alterations in the NMR spectra were clearly related to the degree of tumour response. The most sensitive and earliest marker of tumour regression was a decrease in the phosphomonoester/phosphodiester ratio, parallelled by a gradual increase in the phosphocreatine/inorganic phosphorus quotient. In the resistant tumour lines Hyp 1/H and Hyp 1/R non-responding tumours showed alterations in the 31P NMR spectrum which were similar to those observed during uninfluenced tumour growth. Marked changes in the 31P NMR spectrum were always associated with severe cytotoxic lesions following therapy. The results suggest that the changes detected by 31P NMR spectroscopy following chemotherapy with CDDP are response-specific.
机译：将对顺铂（CDDP）敏感的异种下咽癌（Hyp 1）的磷代谢变化与在肿瘤的两个亚系中发生的磷代谢变化进行比较，其特征为对CDDP的中等或高耐药性（Hyp 1 / H和Hyp 1 / R），ip施用4、8或12 mg CDDP / kg-1。该研究通过体内31P核磁共振（NMR）光谱进行。与NMR实验并行，在相同的实验条件下研究了肿瘤中的细胞动力学和组织学改变。在治疗之前，在这三个肿瘤细胞系之间没有发现主要的含磷代谢产物水平的明显差异。应用CDDP后，NMR谱图中的变化显然与肿瘤反应程度有关。肿瘤消退最敏感，最早的标志是磷酸单酯/磷酸二酯比例的降低，同时磷酸肌酸/无机磷的含量逐渐升高。在抗性肿瘤系Hyp 1 / H和Hyp 1 / R中，无反应的肿瘤在31P NMR光谱中显示出与未受影响的肿瘤生长期间观察到的相似的变化。治疗后31P NMR谱的明显变化始终与严重的细胞毒性病变有关。结果表明，用CDDP化疗后通过31P NMR光谱检测到的变化是响应特异性的。

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