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首页> 美国卫生研究院文献>British Journal of Cancer >The relationship between risk of death from clinical stage 1 cutaneous melanoma and thickness of primary tumour: no evidence for steps in risk. Scottish Melanoma Group.
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The relationship between risk of death from clinical stage 1 cutaneous melanoma and thickness of primary tumour: no evidence for steps in risk. Scottish Melanoma Group.

机译：临床第1期皮肤黑色素瘤死亡风险与原发肿瘤厚度之间的关系：尚无风险步骤的证据。苏格兰黑色素瘤集团。

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Previous reports have suggested that the relationship between survival and thickness of primary cutaneous malignant melanoma is not linear, but that there are natural breakpoints at which survival worsens in a step fashion. Nine hundred and ninety-seven cases of primary cutaneous malignant melanoma less than 9.75 mm thick, excised in Scotland between 1979 and 1983 inclusive, were examined to see if this could be confirmed. An adjusted Cox's regression analysis showed that age, sex, site and thickness were all significant predictors of survival. Thickness was grouped either empirically or by the breakpoints reported by other authors. It was then entered into a model either as a regressor or as a factored variable. The ranges 0-9.75 mm and 0-2 mm were studied separately. In the 0-9.75 mm range the factored variable was a statistically significant better fit than the regressor for each set of breakpoints, including an empirical analysis with eight groups. This suggests that there is no single best fit and that a step-effect is unlikely. Across the 0-2 mm range there was no significant improvement in the fit if thickness was entered as a factored variable, again indicating that a step effect is unlikely. We argue that there is no biological or statistical evidence to support the existence of natural breakpoints.
机译：先前的报道表明，原发性皮肤恶性黑色素瘤的存活率与厚度之间的关系不是线性的，但是存在自然的转折点，存活率会逐步恶化。检查了1979年至1983年间在苏格兰切除的197例厚度小于9.75毫米的原发性皮肤恶性黑色素瘤，以检查是否可以证实。调整后的Cox回归分析表明，年龄，性别，部位和厚度都是生存的重要预测指标。厚度根据经验或其他作者报告的断点进行分组。然后将其作为回归变量或因式变量输入模型中。分别研究了0-9.75 mm和0-2 mm的范围。在0-9.75 mm范围内，对于每组断点，该因子变量在统计上均比回归变量具有更好的拟合度，其中包括对八组进行的经验分析。这表明没有单一的最佳拟合，并且阶跃效应是不可能的。如果将厚度作为因素变量输入，则在0-2 mm的范围内，贴合性没有显着改善，再次表明阶跃效应不太可能。我们认为没有生物学或统计证据来支持自然断点的存在。

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