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首页> 美国卫生研究院文献>British Journal of Cancer >Renal allograft recipients with high susceptibility to cutaneous malignancy have an increased prevalence of human papillomavirus DNA in skin tumours and a greater risk of anogenital malignancy.
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Renal allograft recipients with high susceptibility to cutaneous malignancy have an increased prevalence of human papillomavirus DNA in skin tumours and a greater risk of anogenital malignancy.

机译：对皮肤恶性肿瘤高度敏感的肾同种异体移植受者在皮肤肿瘤中人乳头瘤病毒DNA的患病率增加肛门生殖器恶性肿瘤的风险更高。

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摘要

Renal allograft recipients (RARs) have a well-documented increased incidence of viral warts and cutaneous neoplasia, particularly those with long graft life and high sun exposure. A clinicopathological survey of 69 RARs in south-east Scotland, with follow-up periods of up to 28 years after transplantation, revealed marked variation in patient susceptibility to cutaneous malignancy with concomitant variation in HPV prevalence. Skin cancers were found in 34 patients. Eight patients showed high susceptibility [defined as more than four intraepidermal carcinomas (IECs) or invasive squamous cell carcinomas (SCCs)] 42 had intermediate susceptibility (1-3 IECs or SCCs, or >3 keratoses) and 18 had low susceptibility (< or = 3 keratoses and no cancers). SCCs, IECs and keratoses from the high-susceptibility group were found to have greater prevalences of human papillomavirus (HPV) DNA (56%, 45% and 50% respectively), than SCCs (0%) and IECs (33%) from intermediate-susceptibility RARs and keratoses (36%) from the combined intermediate- and low-susceptibility groups and compared with a group of immunocompetent controls (27%, 20% and 15% respectively). No differences in p53 protein accumulation, determined immunohistochemically, were observed in tumours from the three groups. Categorization of RARs by susceptibility to cutaneous malignancy provides clinically useful information, as significantly more high-susceptibility patients (38%) developed aggressive, potentially lethal anogenital or cutaneous squamous cell cancers than did patients in the intermediate group (5%, P=0.005) or the low-susceptibility group (0%).
机译：肾同种异体移植受体（RAR）的病毒性疣和皮肤瘤形成的发生率有据可查的增加，尤其是移植物寿命长且暴露于阳光下的人。在苏格兰东南部对69个RAR进行的临床病理学调查显示，移植后长达28年的随访期显示，患者对皮肤恶性肿瘤的敏感性显着变化，同时HPV患病率也随之变化。在34名患者中发现了皮肤癌。八名患者表现出高易感性[定义为四种以上的表皮内癌（IEC）或浸润性鳞状细胞癌（SCC）] 42呈中度易感性（1-3 IEC或SCC或> 3个角化病），而18例具有低易感性（<或= 3个角化病，无癌症）。发现高敏感性组的SCC，IEC和角化病的人乳头瘤病毒（HPV）DNA患病率更高（分别为56％，45％和50％），高于中级的SCC（0％）和IEC（33％）易感性RARs和角化酶（36％）来自中，低敏感性组合人群，并与一组具有免疫能力的对照组进行比较（分别为27％，20％和15％）。在三组肿瘤中，未观察到免疫组织化学测定的p53蛋白积累差异。通过对皮肤恶性肿瘤的易感性对RAR进行分类可提供临床有用的信息，因为与中等水平的患者相比，显着更多的高敏感性患者（38％）发展为侵袭性，潜在致死性生殖器或皮肤鳞状细胞癌（5％，P = 0.005）或低敏感性组（0％）。

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