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首页> 美国卫生研究院文献>British Journal of Cancer >Photodetection of early human bladder cancer based on the fluorescence of 5-aminolaevulinic acid hexylester-induced protoporphyrin IX: a pilot study
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Photodetection of early human bladder cancer based on the fluorescence of 5-aminolaevulinic acid hexylester-induced protoporphyrin IX: a pilot study

机译：基于5-氨基戊酸己基酯诱导的原卟啉IX荧光的早期人类膀胱癌的光检测：一项先导研究

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摘要

Exogenous administration of 5-aminolaevulinic acid (ALA) is becoming widely used to enhance the endogenous synthesis of protoporphyrin IX (PpIX) in photodynamic therapy (PDT) and fluorescence photodetection (PD). Recently, results have shown that the chemical modification of ALA into its more lipophilic esters circumvents limitations of ALA-induced PpIX like shallow penetration depth into deep tissue layers and inhomogeneous biodistribution and enhances the total PpIX formation. The present clinical pilot study assesses the feasibility and the advantages of a topical ALA ester-based fluorescence photodetection in the human bladder. In this preliminary study 5-aminolaevulinic acid hexylester (h-ALA) solutions, containing concentrations ranging from 4 to 16 mM, were applied intravesically to 25 patients. Effects of time and drug dose on the resulting PpIX fluorescence level were determined in vivo with an optical fibre-based spectrofluorometer. Neither local nor systemic side-effects were observed for the applied conditions. All conditions used yielded a preferential PpIX accumulation in the neoplastic tissue. Our clinical investigations indicate that with h-ALA a twofold increase of PpIX fluorescence intensity can be observed using 20-fold lower concentrations as compared to ALA. © 1999 Cancer Research Campaign
机译：在光动力疗法（PDT）和荧光光检测（PD）中，外源性施用5-氨基戊戊酸（ALA）已被广泛用于增强原卟啉IX（PpIX）的内源性合成。最近，结果表明，将ALA化学修饰成更具亲脂性的酯可克服ALA诱导的PpIX的局限性，如浅层渗透至深层组织层的深度和不均匀的生物分布，并增强总PpIX的形成。本临床先导研究评估了在人膀胱中局部使用基于ALA酯的荧光光电检测的可行性和优势。在这项初步研究中，对25例患者进行了膀胱内注射，其浓度范围为4至16 mM的5-氨基松香酸己酯（h-ALA）溶液。时间和药物剂量对所得PpIX荧光水平的影响是通过基于光纤的荧光分光光度计在体内确定的。对于所施加的条件，未观察到局部或全身性副作用。使用的所有条件在肿瘤组织中产生优先的PpIX积累。我们的临床研究表明，与ALA相比，使用h-ALA使用低20倍的浓度可以观察到PpIX荧光强度的两倍增加。 ©1999癌症研究运动

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