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首页> 美国卫生研究院文献>British Journal of Cancer >Uterine papillary serous and clear cell carcinomas predict for poorer survival compared to grade 3 endometrioid corpus cancers
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Uterine papillary serous and clear cell carcinomas predict for poorer survival compared to grade 3 endometrioid corpus cancers

机译：子宫乳头状浆液性浆液性和透明细胞癌与3级子宫内膜样体癌相比预测生存较差

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To compare the survival of women with uterine papillary serous carcinoma (UPSC) and clear cell carcinoma (CC) to those with grade 3 endometrioid uterine carcinoma (G3EC). Demographic, pathologic, treatment, and survival information were obtained from the Surveillance, Epidemiology, and End Results Program from 1988 to 2001. Data were analysed using Kaplan–Meier and Cox proportional hazards regression methods. Of 4180 women, 1473 had UPSC, 391 had CC, and 2316 had G3EC cancers. Uterine papillary serous carcinoma and CC patients were older (median age: 70 years and 68 vs 66 years, respectively; P<0.0001) and more likely to be black compared to G3EC (15 and 12% vs 7%; P<0.0001). A higher proportion of UPSC and CC patients had stage III–IV disease compared to G3EC patients (52 and 36% vs 29%; P<0.0001). Uterine papillary serous carcinoma, CC and G3EC patients represent 10, 3, and 15% of endometrial cancers but account for 39, 8, and 27% of cancer deaths, respectively. The 5-year disease-specific survivals for women with UPSC, CC and G3EC were 55, 68, and 77%, respectively (P<0.0001). The survival differences between UPSC, CC and G3EC persist after controlling for stage I–II (74, 82, and 86%; P<0.0001) and stage III–IV disease (33, 40, and 54; P<0.0001). On multivariate analysis, more favourable histology (G3EC), younger age, and earlier stage were independent predictors of improved survival. Women with UPSC and CC of the uterus have a significantly poorer prognosis compared to those with G3EC. These findings should be considered in the counselling, treating and designing of future trials for these high-risk patients.
机译：为了比较子宫乳头状浆液性癌（UPSC）和透明细胞癌（CC）与3级子宫内膜样子宫癌（G3EC）的妇女的生存率。人口，病理，治疗和生存信息来自1988年至2001年的监测，流行病学和最终结果计划。使用Kaplan-Meier和Cox比例风险回归方法分析数据。在4180名女性中，有1473名患有UPSC，391名患有CC和2316名患有G3EC癌症。子宫乳头状浆液性癌和CC患者年龄较大（中位年龄分别为70岁和68岁vs 66岁； P <0.0001），与G3EC相比更可能是黑色的（15％和12％vs 7％； P <0.0001）。与G3EC患者相比，UPSC和CC患者患有III–IV期疾病的比例更高（52％和36％对29％； P <0.0001）。子宫乳头状浆液性癌，CC和G3EC患者分别占子宫内膜癌的10％，3％和15％，但分别占癌症死亡人数的39％，8％和27％。患有UPSC，CC和G3EC的女性的5年疾病特异性存活率分别为55％，68％和77％（P <0.0001）。在控制I–II期（74、82和86％； P <0.0001）和III–IV期疾病（33、40和54； P <0.0001）之后，UPSC，CC和G3EC之间的生存差异仍然存在。在多变量分析中，更有利的组织学（G3EC），年龄较小和早期是生存率提高的独立预测因素。与G3EC的女性相比，患有UPSC和子宫CC的女性的预后明显较差。这些发现应在针对这些高危患者的未来治疗的咨询，治疗和设计中加以考虑。

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