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ABCB1 (MDR1) induction defines a common resistance mechanism in paclitaxel- and olaparib-resistant ovarian cancer cells

机译：ABCB1（MDR1）诱导定义了耐紫杉醇和奥拉帕尼的卵巢癌细胞的常见耐药机制

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Background: Clinical response to chemotherapy for ovarian cancer is frequently compromised by the development of drug-resistant disease. The underlying molecular mechanisms and implications for prescription of routinely prescribed chemotherapy drugs are poorly understood.

机译：背景：对卵巢癌化学疗法的临床反应经常因耐药性疾病的发展而受到损害。对常规处方化疗药物处方的潜在分子机制和含义了解甚少。

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期刊名称 British Journal of Cancer
作者
Aparajitha Vaidyanathan; Lynne Sawers; Anne-Louise Gannon; Probir Chakravarty; Alison L Scott; Susan E Bray; Michelle J Ferguson; Gillian Smith;
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作者单位

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年(卷),期 2016(115),4
年度 2016
页码 431–441
总页数 11
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
ovarian cancer drug resistance chemotherapy paclitaxel olaparib PARP inhibitor ABCB1 MDR1;

机译：卵巢癌;耐药性;化学疗法;紫杉醇;奥拉帕尼;PARP抑制剂;ABCB1;MDR1;

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专利

1. ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: A comprehensive analysis from the Ovarian Cancer Association Consortium and the Cancer Genome Atlas [J] . JohnattyS.E., BeesleyJ., GaoB., Gynecologic Oncology: An International Journal . 2013,第1期

机译：ABCB1（MDR1）多态性与卵巢癌的进展和生存：卵巢癌协会联合会和癌症基因组图谱的综合分析
2. Common germline MDR1/ABCB1 functional polymorphisms and haplotypes modify susceptibility to colorectal cancers with high microsatellite instability. [J] . Potocnik U, Glavac D, Dean M Cancer genetics and cytogenetics . 2008,第1期

机译：常见的种系MDR1 / ABCB1功能多态性和单倍型改变了对具有高微卫星不稳定性的大肠癌的敏感性。
3. MiR-200c sensitizes Olaparib-resistant ovarian cancer cells by targeting Neuropilin 1 [J] . Enrica Vescarelli, Giulia Gerini, Francesca Megiorni, Journal of experimental & clinical cancer research : . 2020,第1期

机译：miR-200c通过靶向神经毛素1来敏感奥拉帕里布抗性卵巢癌细胞
4. MDRView: a visualization of the polymorphisms of MDR1(ABCB1) GENE in breast cancer [C] . Xhemo E., Fajac A., Boire J.-Y., Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2007

机译：MDRView：乳腺癌中MDR1（ABCB1）基因多态性的可视化
5. Molecular mechanism of apoptosis induction by SHetA2 in ovarian cancer cells. [D] . Chengedza, Shylet. 2009

机译：SHetA2诱导卵巢癌细胞凋亡的分子机制。
6. ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: A comprehensive analysis from the Ovarian Cancer Association Consortium and The Cancer Genome Atlas [O] . Sharon E. Johnatty, Jonathan Beesley, Bo Gao, -1

机译：ABCB1（MDR1）多态性与卵巢癌的进展和生存：卵巢癌协会联合会和癌症基因组图谱的综合分析
7. ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: A comprehensive analysis from the Ovarian Cancer Association Consortium and the Cancer Genome Atlas [O] . Johnatty, SE, Beesley, J, Gao, B, 2013

机译：ABCB1（MDR1）多态性与卵巢癌的进展和生存：卵巢癌协会联合会和癌症基因组图谱的综合分析

ABCB1 (MDR1) induction defines a common resistance mechanism in paclitaxel- and olaparib-resistant ovarian cancer cells

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