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首页> 美国卫生研究院文献>Journal of the Royal Society Interface >The evolution of developmental patterning under genetic duplication constraints
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The evolution of developmental patterning under genetic duplication constraints

机译：遗传复制约束条件下发育模式的演变

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摘要

Of considerable interest are the evolutionary and developmental origins of complex, adaptive structures and the mechanisms that stabilize these structures. We consider the relationship between the evolutionary process of gene duplication and deletion and the stability of morphogenetic patterns produced by interacting activators and inhibitors. We compare the relative stability of patterns with a single activator and inhibitor (two-dimensional system) against a ‘redundant’ system with two activators or two inhibitors (three-dimensional system). We find that duplication events can both expand and contract the space of patterns. We study developmental robustness in terms of stochastic escape times from this space, also known as a ‘canalization potential’. We embed the output of pattern formation into an explicit evolutionary model of gene duplication, gene loss and variation in the steepness of the canalization potential. We find that under all constant conditions, the system evolves towards a preference for steep potentials associated with low phenotypic variability and longer lifespans. This preference leads to an overall decrease in the density of redundant genotypes as developmental robustness neutralizes the advantages of genetic robustness.
机译：令人关注的是复杂的适应性结构的进化和发展起源以及稳定这些结构的机制。我们考虑了基因复制和缺失的进化过程与激活剂和抑制剂相互作用产生的形态发生模式的稳定性之间的关系。我们将单一激活剂和抑制剂（二维系统）与具有两个激活剂或两种抑制剂的“冗余”系统（三维系统）的模式相对稳定性进行了比较。我们发现重复事件可以扩展和缩小模式空间。我们从该空间的随机逃逸时间（也称为“运河化潜力”）研究发展的稳健性。我们将模式形成的输出嵌入到基因复制，基因丢失和渠化陡度变化的显式进化模型中。我们发现，在所有恒定条件下，该系统朝着与低表型变异性和更长寿命相关的陡峭电位的方向发展。由于发育稳健性中和了遗传稳健性的优势，这种偏好导致冗余基因型密度的总体下降。

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