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Efficacy of sonographic and biological pleurodesis indicators of malignant pleural effusion (SIMPLE): protocol of a randomised controlled trial

机译:超声检查和恶性胸腔积液的生物性胸膜固定术指标的有效性(SIMPLE):一项随机对照试验的方案

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摘要

IntroductionMalignant pleural effusion (MPE) is common and currently in UK there are an estimated 50 000 new cases of MPE per year. Talc pleurodesis remains one of the most popular methods for fluid control. The value of thoracic ultrasound (TUS) imaging, before and after pleurodesis, in improving the quality and efficacy of care for patients with MPE remains unknown. Additionally, biomarkers of successful pleurodesis including measurement of pleural fluid proteins have not been validated in prospective studies.The SIMPLE trial is an appropriately powered, multicentre, randomised controlled trial designed to assess ’by the patient bedside' use of TUS imaging and pleural fluid analysis in improving management of MPE.
机译:简介恶性胸腔积液(MPE)很常见,目前在英国每年估计有5万例新的MPE病例。滑石粉胸膜固定术仍然是最流行的液体控制方法之一。在胸膜固定术之前和之后,胸腔超声(TUS)成像在改善MPE患者的护理质量和疗效方面的价值仍然未知。此外,成功进行胸膜固定术的生物标志物(包括胸膜液蛋白的测定)尚未在前瞻性研究中得到验证.SIMPLE试验是一项具有适当能力的多中心随机对照试验,旨在评估TUS成像和胸膜液分析在患者床旁的使用情况改善MPE的管理。

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