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首页> 美国卫生研究院文献>BMJ Open >Rationale and study design for an individualised perioperative open-lung ventilatory strategy with a high versus conventional inspiratory oxygen fraction (iPROVE-O2) and its effects on surgical site infection: study protocol for a randomised controlled trial
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Rationale and study design for an individualised perioperative open-lung ventilatory strategy with a high versus conventional inspiratory oxygen fraction (iPROVE-O2) and its effects on surgical site infection: study protocol for a randomised controlled trial

机译：相对于常规吸氧分数（iPROVE-O2）高的个性化围手术期开放肺通气策略的原理和研究设计及其对手术部位感染的影响：一项随机对照试验的研究方案

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IntroductionSurgical site infection (SSI) is a serious postoperative complication that increases morbidity and healthcare costs. SSIs tend to increase as the partial pressure of tissue oxygen decreases: previous trials have focused on trying to reduce them by comparing high versus conventional inspiratory oxygen fractions (FIO2) in the perioperative period but did not use a protocolised ventilatory strategy. The open-lung ventilatory approach restores functional lung volume and improves gas exchange, and therefore it may increase the partial pressure of tissue oxygen for a given FIO2. The trial presented here aims to compare the efficacy of high versus conventional FIO2 in reducing the overall incidence of SSIs in patients by implementing a protocolised and individualised global approach to perioperative open-lung ventilation.
机译：简介手术部位感染（SSI）是一种严重的术后并发症，会增加发病率和医疗保健费用。随着组织氧分压的降低，SSI趋于增加：以前的研究集中在通过比较围手术期的高与常规吸氧分数（FIO2）来试图降低它们，但并未采用协议的通气策略。开放肺通气方法可恢复肺功能，并改善气体交换，因此对于给定的FIO2，它可能会增加组织氧的分压。本文介绍的试验旨在通过采用协议化和个性化的围手术期开放式肺通气方法，比较高FIO2与常规FIO2在降低患者SSI总体发生率方面的疗效。

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