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首页> 美国卫生研究院文献>BMJ Open >Multicentre randomised controlled trial to investigate usefulness of the rapid diagnostic βLACTA test performed directly on bacterial cell pellets from respiratory urinary or blood samples for the early de-escalation of carbapenems in septic intensive care unit patients: the BLUE-CarbA protocol
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Multicentre randomised controlled trial to investigate usefulness of the rapid diagnostic βLACTA test performed directly on bacterial cell pellets from respiratory urinary or blood samples for the early de-escalation of carbapenems in septic intensive care unit patients: the BLUE-CarbA protocol

机译：多中心随机对照试验研究对呼吸道泌尿或血液样本中的细菌细胞沉淀物直接进行快速诊断性βLACTA测试对脓毒症重症监护病房患者碳青霉烯早期降级的作用：BLUE-CarbA方案

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IntroductionThe dramatic increase of the incidence of infections caused by extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE) has led to an increase of 50% of carbapenem consumption all around Europe in only 5 years. This favours the spread of carbapenem-resistant Gram-negative bacilli (GNB), causing life-threatening infections. In order to limit use of carbapenems for infections actually due to ESBL-PE, health authorities promote the use of rapid diagnostic tests of bacterial resistance. The objective of this work conducted in the intensive care unit (ICU) is to determine whether an early de-escalation of empirical carbapenems guided by the result of the βLACTA test is not inferior to the reference strategy of de-escalating carbapenems after the antibiogram result has been rendered.
机译：简介广谱产生β-内酰胺酶的肠杆菌科细菌（ESBL-PE）引起的感染发生率急剧增加，仅在短短5年的时间内，整个欧洲的碳青霉烯消耗量就增加了50％。这有利于对碳青霉烯类耐药的革兰氏阴性菌（GNB）的传播，导致威胁生命的感染。为了限制将碳青霉烯类药物用于实际上由于ESBL-PE引起的感染，卫生当局提倡使用细菌耐药性的快速诊断测试。重症监护病房（ICU）开展这项工作的目的是确定在抗菌素检测结果后，由βLACTA测试结果指导的经验碳青霉烯类药物的早期降级是否不劣于碳青霉烯类药物的降级参考策略。已呈现。

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