Erythropoietic and non-erythropoietic functions of erythropoietin in mouse models

机译：促红细胞生成素在小鼠模型中的促红细胞生成和非促红细胞生成功能

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AbstractAs the basic function of erythropoietin (Epo) is stimulation of red blood cell production, systemic overexpression of Epo results in erythrocytosis. The patho-physiological consequences of chronically elevated red blood cell counts have been studied in Epo overexpressing mice. Genetically modified mice, however, have also played an important role in discovering multiple additional functions of Epo besides stimulating erythrocyte production. Non-erythropoietic functions of Epo are widespread and play a role in organogenesis during early embryonic development and in tissue protection in ischaemic diseases. Future work in the field will most likely focus on these additional functions of Epo, which have great clinical potential.

机译：摘要由于促红细胞生成素（Epo）的基本功能是刺激红细胞生成，因此Epo的系统性过表达会导致红细胞增多。在过表达Epo的小鼠中研究了慢性红细胞计数长期升高的病理生理后果。然而，转基因小鼠除了刺激红细胞的产生外，在发现Epo的多种其他功能中也发挥了重要作用。 Epo的非促红细胞功能广泛存在，并在早期胚胎发育期间的器官发生和缺血性疾病的组织保护中发挥作用。该领域未来的工作很可能将集中在具有巨大临床潜力的Epo的这些附加功能上。

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期刊名称 The Journal of Physiology
作者
Johannes Vogel; Max Gassmann;
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作者单位

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年(卷),期 2011(589),Pt 6
年度 2011
页码 1259–1264
总页数 6
原文格式 PDF
正文语种
中图分类神经科学;人体生理学;
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1. Erythropoietic and non-erythropoietic functions of erythropoietin in mouse models. [J] . Vogel J, Gassmann M The Journal of Physiology . 2011,第6期

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6. A non-erythropoietic peptide derivative of erythropoietin decreases susceptibility to diet-induced insulin resistance in mice [O] . M Collino, E Benetti, M Rogazzo, 2014

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7. Erythropoietic and non-erythropoietic functions of erythropoietin in mouse models [O] . Vogel, Johannes, Gassmann, Max 2011

机译：促红细胞生成素在小鼠模型中的促红细胞生成和非促红细胞生成功能

Erythropoietic and non-erythropoietic functions of erythropoietin in mouse models

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