首页> 美国卫生研究院文献>BMJ Case Reports >Novel treatment (new drug/intervention; established drug/procedure in new situation): Combination treatment of intravenous immunoglobulin and cultivated oral mucosal epithelial transplantation for ocular cicatricial pemphigoid
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Novel treatment (new drug/intervention; established drug/procedure in new situation): Combination treatment of intravenous immunoglobulin and cultivated oral mucosal epithelial transplantation for ocular cicatricial pemphigoid

机译:新疗法(新药/干预;新情况下已确立的药物/程序):静脉免疫球蛋白联合培养的口腔粘膜上皮移植治疗眼瘢痕类天疱疮

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摘要

Ocular cicatricial pemphigoid (OCP) is a progressive cicatrising autoimmune disease affecting the skin and mucous membranes, including ocular surface epithelia. Although systemic immunosuppression is advocated, both progression of ocular surface inflammation and systemic side effects remain a problem. For the treatment of an active OCP, both control of autoimmune reaction and ocular surface reconstruction are necessary. We believe that the combination of intravenous immunoglobulin (IVIg) and cultivated oral mucosal epithelial transplantation (COMET) is a powerful treatment modality while minimising the risk of postoperative consequences inevitably associated with immunosuppression. A patient with OCP successfully treated by a combination of IVIg and COMET is described here.
机译:眼瘢痕类天疱疮(OCP)是一种进行性瘢痕性自身免疫病,会影响皮肤和粘膜(包括眼表上皮细胞)。尽管提倡全身性免疫抑制,但眼表炎症的进展和全身性副作用仍然是一个问题。对于活性OCP的治疗,必须同时控制自身免疫反应和眼表重建。我们认为静脉免疫球蛋白(IVIg)和人工口腔粘膜上皮移植(COMET)的结合是一种有效的治疗方法,同时将不可避免地与免疫抑制相关的术后后果的风险降至最低。此处介绍了通过IVIg和COMET联合治疗成功的OCP患者。

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