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首页> 美国卫生研究院文献>BMC Veterinary Research >Administration of trimethoprim-sulphadimidine does not improve healing of glandular gastric ulceration in horses receiving omeprazole: a randomised blinded clinical study
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Administration of trimethoprim-sulphadimidine does not improve healing of glandular gastric ulceration in horses receiving omeprazole: a randomised blinded clinical study

机译：给予甲氧苄啶-磺胺嘧啶并不能改善接受奥美拉唑的马的腺胃溃疡的愈合：一项随机盲法的临床研究

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BackgroundInterest in Equine Gastric Ulcer Syndrome (EGUS) has recently increased in part due to a growing awareness of the differences between squamous and glandular disease. The pathophysiology and epidemiology of squamous and glandular disease are different and recently it has been shown that the response of glandular gastric ulceration to monotherapy with omeprazole is poor. Given these differences it has been recommended that specific treatment guidelines be formulated for equine glandular disease and that adjunctive therapies be investigated. Along these lines it has been suggested that the addition of antimicrobials may enhance healing. The objective of this study was to investigate whether the addition of trimethoprim-sulphadimidine to omeprazole therapy would result in superior healing of naturally occurring equine glandular ulceration compared with omeprazole monotherapy.
机译：背景技术马胃溃疡综合症（EGUS）的兴趣近来有所增加，部分原因是人们对鳞状和腺性疾病之间的差异认识不断提高。鳞状和腺性疾病的病理生理学和流行病学不同，最近已显示，奥美拉唑单药治疗的腺性胃溃疡反应较差。考虑到这些差异，建议针对马腺疾病制定具体的治疗指南，并研究辅助治疗。沿着这些思路，已经提出添加抗微生物剂可以促进愈合。这项研究的目的是调查与奥美拉唑单一疗法相比，在奥美拉唑疗法中添加甲氧苄啶-磺胺二甲嘧啶是否会导致自然发生的马腺溃疡愈合更佳。

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