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A detection of benzimidazole resistance-associated SNPs in the isotype-1 β-tubulin gene in Haemonchus contortus from wild blue sheep (Pseudois nayaur) sympatric with sheep in Helan Mountains China

机译：贺兰山野生蓝绵羊与绵羊同伴的捻转血矛线虫中1型β微管蛋白基因中与苯并咪唑抗药性相关的SNPs的检测

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BackgroundBenzimidazole (BZ) resistance is an increasingly serious problem due to the excessive use of this anthelmintic for controlling Haemonchus contortus, which is one of the major gastrointestinal nematodes infecting small ruminants worldwide. Three known single nucleotide polymorphisms (SNPs), F167Y (TAC), E198A (GCA) and F200Y (TAC), in the isotype-1 β-tubulin gene of H. contortus are associated with BZ resistance. Comprehending the spread and origins of BZ resistance-associated SNPs has important implications for the control of this nematode.

机译：背景技术由于过量使用该驱虫剂来控制扭曲的Haemonchus contortus，它是耐药性日益严重的问题，而Haemonchus contortus是全世界感染小反刍动物的主要胃肠道线虫之一。扭转嗜血杆菌的1型β微管蛋白基因中三个已知的单核苷酸多态性（SNPs）F167Y（TAC），E198A（GCA）和F200Y（TAC）与BZ抗性相关。理解与BZ抗性相关的SNP的扩散和起源对于控制该线虫具有重要意义。

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期刊名称 BMC Veterinary Research
作者
Dong-dong Shen; Zhi-wei Peng; Min Hu; Zong-ze Zhang; Zhi-jun Hou; Zhen-sheng Liu;
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作者单位

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年(卷),期 2019(15),-1
年度 2019
页码 89
总页数 9
原文格式 PDF
正文语种
中图分类动物医学（兽医学）;
关键词
Blue sheep Haemonchus contortus Isotype-1 β-tubulin gene Benzimidazole resistance Helan Mountains;

机译：蓝羊;捻转血矛线虫;同型1β微管蛋白基因;苯并咪唑抗性;贺兰山;

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专利

1. A detection of benzimidazole resistance-associated SNPs in the isotype-1 β-tubulin gene in Haemonchus contortus from wild blue sheep ( Pseudois nayaur ) sympatric with sheep in Helan Mountains, China [J] . Dong-dong Shen, Zhi-wei Peng, Min Hu, BMC Veterinary Research . 2019,第1期

机译：贺兰山野生蓝羊同胞羊中的变形金刚梭形虫1型β微管蛋白基因中与苯并咪唑抗药性相关的SNPs的检测
2. Comparative analysis of winter diets and habitat use by the sympatric blue sheep (Pseudois nayaur) and Alashan red deer (Cervus alashanicus) in the Helan Mountains, China [J] . Liu Zhensheng, Zhu Zhaoling, Gao Hui, Folia Zoologica: International Journal of Vertebratology . 2018,第1期

机译：Sympatric Blue Sheep（伪龙龙）与阿拉罕红鹿（宫殿山谷）在亥琅山中冬季饮食与栖息地使用的比较分析
3. Two benzimidazole resistance-associated SNPs in the isotype-1 @b-tubulin gene predominate in Haemonchus contortus populations from eight regions in China [J] . Zongze Zhang, Robin B. Gasser, Xin Yang, International Journal for Parasitology: Drugs and Drug Resistance . 2016,第3期

机译：来自中国八个地区的捻转血矛线虫种群中的isotype-1 @ b-tubulin基因中的两个苯并咪唑抗药性相关的SNP占主导地位。
4. Molecular approaches for conservation of endangered giant argali sheep (Ovis ammon) and dwarf blue sheep (Pseudois nayaur schaeferi) in Asia. [D] . Feng, Jiu. 2001

机译：在亚洲保护濒临灭绝的巨型盘羊（Ovis ammon）和矮蓝绵羊（Pseudois nayaur schaeferi）的分子方法。
5. Genetic diversity of Haemonchus contortus isolated from sympatric wild blue sheep (Pseudois nayaur) and sheep in Helan Mountains China [O] . Dong-dong Shen, Ji-fei Wang, Dan-yu Zhang, 2017

机译：贺兰山地区同伴野生蓝羊（Pseudois nayaur）和羊中分离到的Haemonchus contortus的遗传多样性
6. Comparative analysis of winter diets and habitat use by the sympatric blue sheep (Pseudois nayaur) and Alashan red deer (Cervus alashanicus) in the Helan Mountains, China [O] . Zhensheng Liu, Zhaoling Zhu, Hui Gao, 2018

机译：冬季蓝羊（伪龙龙）与阿拉罕红鹿（Cervus Alashanicus）在亥安山大学的冬季饮食与栖息地使用的比较分析

A detection of benzimidazole resistance-associated SNPs in the isotype-1 β-tubulin gene in Haemonchus contortus from wild blue sheep (Pseudois nayaur) sympatric with sheep in Helan Mountains China

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