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Precision and type I error rate in the presence of genotype errors and missing parental data: a comparison between the original transmission disequilibrium test (TDT) and TDTae statistics

机译：在存在基因型错误和缺失父母数据的情况下的精度和I型错误率：原始传输不平衡测试（TDT）与TDTae统计数据之间的比较

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BackgroundTwo factors impacting robustness of the original transmission disequilibrium test (TDT) are: i) missing parental genotypes and ii) undetected genotype errors. While it is known that independently these factors can inflate false-positive rates for the original TDT, no study has considered either the joint impact of these factors on false-positive rates or the precision score of TDT statistics regarding these factors. By precision score, we mean the absolute difference between disease gene position and the position of markers whose TDT statistic exceeds some threshold.

机译：背景技术影响原始传输不平衡测试（TDT）的鲁棒性的两个因素是：i）父母基因型缺失和ii）未检测到基因型错误。虽然已知这些因素可以独立地增加原始TDT的假阳性率，但尚无研究考虑这些因素对假阳性率的联合影响或TDT统计精确度得分。精确度评分是指疾病基因位置与TDT统计量超过某个阈值的标记物位置之间的绝对差。

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期刊名称 BMC Genetics
作者
Sandra Barral; Chad Haynes; Mark A Levenstien; Derek Gordon;
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年(卷),期 2005(6),Suppl 1
年度 2005
页码 S150
总页数 5
原文格式 PDF
正文语种
中图分类遗传学;
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专利

1. An evaluation of power and type I error of single-nucleotide polymorphism transmission/disequilibrium-based statistical methods under different family structures, missing parental data, and population stratification [J] . Nicodemus KK, Luna A, Shugart YY The American Journal of Human Genetics . 2007,第1期

机译：在不同家庭结构，缺失父母数据和人群分层的情况下，评估基于单核苷酸多态性传播/不平衡的统计方法的功效和I型错误
2. Examining the effect of linkage disequilibrium between markers on the Type I error rate and power of nonparametric multipoint linkage analysis of two-generation and multigenerational pedigrees in the presence of missing genotype data. [J] . Kim Y, Duggal P, Gillanders EM, Genetic epidemiology. . 2008,第1期

机译：在缺少基因型数据的情况下，检查标记之间的连锁不平衡对两代和多代谱系的I型错误率和非参数多点连锁分析能力的影响。
3. A transmission disequilibrium test for general pedigrees that is robust to the presence of random genotyping errors and any number of untyped parents. [J] . Gordon D, Haynes C, Johnnidis C, European journal of human genetics: EJHG . 2004,第9期

机译：通用谱系的传输不平衡测试对存在随机基因分型错误和任何数量的未分型双亲都存在的鲁棒性。
4. Statistical aspects of the transmission/disequilibrium test (TDT) [C] . Warren J. Ewens Joint AMS-IMS-SIAM Summer Conference on Statistics in Molecular Biology . 1999

机译：透射/不平衡测试（TDT）的统计方面
5. Likelihood ratio tests for association with multiple disease susceptibility alleles, genotyping errors, or missing parental data. [D] . Morris, Richard Wayne. 2003

机译：与多个疾病易感性等位基因，基因分型错误或父母数据缺失相关的可能性比测试。
6. Impact of Genotyping Errors on Type I Error Rate of the Haplotype-Sharing Transmission/Disequilibrium Test (HS-TDT) [O] . Michael Knapp, Tim Becker 2004

机译：基因分型错误对单倍型共享传递/不平衡检验（HS-TDT）的I型错误率的影响
7. Precision and type I error rate in the presence of genotype errors and missing parental data: a comparison between the original transmission disequilibrium test (TDT) and TDTae statistics [O] . Sandra Barral, Chad Haynes, Mark A Levenstien, 2005

机译：在存在基因型错误和缺失父母数据的情况下的精度和I型错误率：原始传输不平衡测试（TDT）与TDTae统计数据之间的比较

Precision and type I error rate in the presence of genotype errors and missing parental data: a comparison between the original transmission disequilibrium test (TDT) and TDTae statistics

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