首页> 美国卫生研究院文献>BMC Genetics >Pseudogenization of the MCP-2/CCL8 chemokine gene in European rabbit (genus Oryctolagus) but not in species of Cottontail rabbit (Sylvilagus) and Hare (Lepus)
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Pseudogenization of the MCP-2/CCL8 chemokine gene in European rabbit (genus Oryctolagus) but not in species of Cottontail rabbit (Sylvilagus) and Hare (Lepus)

机译:MCP-2 / CCL8趋化因子基因在欧洲兔(Oryctolagus属)中发生假源化但在棉尾兔(Sylvilagus)和野兔(Lepus)中却没有

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摘要

BackgroundRecent studies in human have highlighted the importance of the monocyte chemotactic proteins (MCP) in leukocyte trafficking and their effects in inflammatory processes, tumor progression, and HIV-1 infection. In European rabbit (Oryctolagus cuniculus) one of the prime MCP targets, the chemokine receptor CCR5 underwent a unique structural alteration. Until now, no homologue of MCP-2/CCL8a, MCP-3/CCL7 or MCP-4/CCL13 genes have been reported for this species. This is interesting, because at least the first two genes are expressed in most, if not all, mammals studied, and appear to be implicated in a variety of important chemokine ligand-receptor interactions. By assessing the Rabbit Whole Genome Sequence (WGS) data we have searched for orthologs of the mammalian genes of the MCP-Eotaxin cluster.
机译:背景技术人类的最新研究强调了单核细胞趋化蛋白(MCP)在白细胞运输中的重要性及其在炎症过程,肿瘤进展和HIV-1感染中的作用。在欧洲兔子(Oryctolagus cuniculus)的主要MCP靶标之一中,趋化因子受体CCR5经历了独特的结构改变。迄今为止,尚未报道该物种的MCP-2 / CCL8 a ,MCP-3 / CCL7或MCP-4 / CCL13基因的同源物。这很有趣,因为至少前两个基因在大多数(如果不是全部)研究的哺乳动物中表达,并且似乎与多种重要的趋化因子配体-受体相互作用有关。通过评估兔全基因组序列(WGS)数据,我们搜索了MCP-趋化因子簇的哺乳动物基因的直系同源基因。

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