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The main WAP isoform usually found in camel milk arises from the usage of an improbable intron cryptic splice site in the precursor to mRNA in which a GC-AG intron occurs

机译：通常在骆驼奶中发现的主要WAP同工型是由于在发生GC-AG内含子的mRNA的前体中使用了不太可能的内含子隐蔽剪接位点而引起的

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BackgroundWhey acidic protein (WAP) is a major protein identified in the milk of several mammalian species with cysteine-rich domains known as four-disulfide cores (4-DSC). The organization of the eutherian WAP genes is highly conserved through evolution. It has been proposed that WAP could play an important role in regulating the proliferation of mammary epithelial cells. A bacteriostatic activity was also reported. Conversely to the other mammalian species expressing WAP in their milk, camel WAP contains 4 additional amino acid residues at the beginning of the second 4-DSC domain, introducing a phosphorylation site. The aim of this study was to elucidate the origin of this specificity, which possibly impacts its physiological functions.

机译：背景乳清酸蛋白（WAP）是在几种哺乳动物的乳汁中鉴定出的主要蛋白，这些乳汁具有富含半胱氨酸的结构域，称为四二硫键核心（4-DSC）。通过进化，高度保守的WAP基因的组织是高度保守的。已经提出，WAP可以在调节乳腺上皮细胞的增殖中起重要作用。还报道了抑菌活性。与在其乳汁中表达WAP的其他哺乳动物相反，骆驼WAP在第二个4-DSC域的开始处包含4个其他氨基酸残基，从而引入了磷酸化位点。这项研究的目的是阐明这种特异性的起源，这可能会影响其生理功能。

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期刊名称 BMC Genetics
作者
Alma Ryskaliyeva; Céline Henry; Guy Miranda; Bernard Faye; Gaukhar Konuspayeva; Patrice Martin;
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作者单位

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年(卷),期 2019(20),-1
年度 2019
页码 14
总页数 10
原文格式 PDF
正文语种
中图分类遗传学;
关键词
Camel Milk Whey protein Splicing Genetic polymorphism;

机译：骆驼;牛奶;乳清蛋白;剪接;遗传多态性;

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1. The main WAP isoform usually found in camel milk arises from the usage of an improbable intron cryptic splice site in the precursor to mRNA in which a GC-AG intron occurs [J] . Alma Ryskaliyeva, Céline Henry, Guy Miranda, BMC Genetics . 2019,第1期

机译：通常在骆驼奶中发现的主要WAP异构体是由于在发生GC-AG内含子的mRNA前体中使用了不太可能的内含子隐蔽剪接位点
2. Test of intron predictions reveals novel splice sites, alternatively spliced mRNAs and new introns in meiotically regulated genes of yeast. [J] . Davis CA, Grate L, Spingola M, Nucleic Acids Research . 2000,第8期

机译：内含子预测的测试揭示了酵母减数分裂调控基因中的新剪接位点，选择性剪接的mRNA和新内含子。
3. Test of intron predictions reveals novel splice sites, alternatively spliced mRNAs and new introns in meiotically regulated genes of yeast [J] . Carrie A. Davis, Leslie Grate, Manuel Ares Jr, Nucleic acids research . 2000,第8期

机译：内含子预测的测试揭示了酵母减数分裂调控基因中的新剪接位点，选择性剪接的mRNA和新内含子
4. Test of intron predictions reveals novel splice sites alternatively spliced mRNAs and new introns in meiotically regulated genes of yeast [O] . Carrie A. Davis, Leslie Grate, Marc Spingola, 2000

机译：内含子预测的测试揭示了酵母减数分裂调控基因中的新剪接位点可变剪接的mRNA和新的内含子
5. Test of intron predictions reveals novel splice sites, alternatively spliced mRNAs and new introns in meiotically regulated genes of yeast [O] . Davis, Carrie A., Grate, Leslie, Spingola, Marc, 2000

机译：内含子预测的测试揭示了酵母减数分裂调控基因中的新剪接位点，可变剪接的mRNA和新的内含子

The main WAP isoform usually found in camel milk arises from the usage of an improbable intron cryptic splice site in the precursor to mRNA in which a GC-AG intron occurs

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