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首页> 美国卫生研究院文献>BMC Systems Biology >Quantifying the roles of random motility and directed motility using advection-diffusion theory for a 3T3 fibroblast cell migration assay stimulated with an electric field
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Quantifying the roles of random motility and directed motility using advection-diffusion theory for a 3T3 fibroblast cell migration assay stimulated with an electric field

机译：使用对流扩散理论对电场刺激的3T3成纤维细胞迁移实验中的随机运动和定向运动的作用进行定量

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BackgroundDirected cell migration can be driven by a range of external stimuli, such as spatial gradients of: chemical signals (chemotaxis); adhesion sites (haptotaxis); or temperature (thermotaxis). Continuum models of cell migration typically include a diffusion term to capture the undirected component of cell motility and an advection term to capture the directed component of cell motility. However, there is no consensus in the literature about the form that the advection term takes. Some theoretical studies suggest that the advection term ought to include receptor saturation effects. However, others adopt a much simpler constant coefficient. One of the limitations of including receptor saturation effects is that it introduces several additional unknown parameters into the model. Therefore, a relevant research question is to investigate whether directed cell migration is best described by a simple constant tactic coefficient or a more complicated model incorporating saturation effects.
机译：背景定向的细胞迁移可以由一系列外部刺激来驱动，例如以下的空间梯度：化学信号（趋化性）；粘附部位（触觉）；或温度（热轴）。细胞迁移的连续模型通常包括捕获细胞运动的非定向成分的扩散项和捕获细胞运动的定向成分的对流项。但是，在文献中，对流项的形式尚无共识。一些理论研究表明，对流项应包括受体饱和效应。但是，其他采用的常数系数要简单得多。包括受体饱和效应的局限性之一是它将几个其他未知参数引入模型。因此，一个相关的研究问题是要研究通过简单的恒定策略系数还是结合饱和效应的更复杂模型来最好地描述定向细胞迁移。

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