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首页> 美国卫生研究院文献>BMC Structural Biology >Functional region prediction with a set of appropriate homologous sequences-an index for sequence selection by integrating structure and sequence information with spatial statistics
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Functional region prediction with a set of appropriate homologous sequences-an index for sequence selection by integrating structure and sequence information with spatial statistics

机译：具有一组适当同源序列的功能区预测-通过将结构和序列信息与空间统计信息集成在一起来进行序列选择的索引

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BackgroundThe detection of conserved residue clusters on a protein structure is one of the effective strategies for the prediction of functional protein regions. Various methods, such as Evolutionary Trace, have been developed based on this strategy. In such approaches, the conserved residues are identified through comparisons of homologous amino acid sequences. Therefore, the selection of homologous sequences is a critical step. It is empirically known that a certain degree of sequence divergence in the set of homologous sequences is required for the identification of conserved residues. However, the development of a method to select homologous sequences appropriate for the identification of conserved residues has not been sufficiently addressed. An objective and general method to select appropriate homologous sequences is desired for the efficient prediction of functional regions.
机译：背景技术检测蛋白质结构上的保守残基簇是预测功能性蛋白质区域的有效策略之一。基于这种策略，已经开发了各种方法，例如Evolutionary Trace。在这样的方法中，通过比较同源氨基酸序列来鉴定保守残基。因此，同源序列的选择是关键步骤。从经验上知道，鉴定保守残基需要在同源序列组中一定程度的序列差异。然而，尚未充分解决选择适合于鉴定保守残基的选择同源序列的方法的开发。为了有效地预测功能区，需要一种选择适当同源序列的客观通用方法。

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