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Rad and Rem are non‐canonical G‐proteins with respect to the regulatory role of guanine nucleotide binding in CaV1.2 channel regulation

机译：就鸟嘌呤核苷酸结合在CaV1.2通道调控中的调控作用而言Rad和Rem是非经典G蛋白

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Key points class="unordered" style="list-style-type:disc" id="tjp6876-list-0001">RGK (Rad, Rem, Rem2, Gem/Kir) proteins are small monomeric G‐proteins implicated in various cellular functions and disease states. All RGK proteins potently inhibit voltage‐gated calcium (CaV) channels.It is unclear whether RGK proteins are regulated by guanine nucleotide binding in a manner that conforms to a canonical G‐protein regulation paradigm.We utilized strategic Rad and Rem mutants together with a range of functional readouts (CaV1.2 currents, Ca²⁺ transients, CaVβ binding) in heterologous cells and cardiomyocytes to determine whether the function of these RGK proteins is regulated in a canonical manner.Our results demonstrate that Rad and Rem are non‐canonical G‐proteins with respect to the regulatory role of their guanine nucleotide binding domain in CaV1.2 channel regulation.Our findings offer deepened insights into cellular mechanisms governing RGK regulation and function, and contribute towards our understanding of their pathophysiological roles.

机译：关键点 class =“ unordered” style =“ list-style-type：disc” id =“ tjp6876-list-0001”> <！-list-behavior = unordered prefix-word = mark-type = disc max- label-size = 0-> liliRGK（Rad，Rem，Rem2，Gem / Kir）蛋白是小的单体G蛋白，涉及各种细胞功能和疾病状态。所有RGK蛋白均有效抑制电压门控钙（CaV）通道。目前尚不清楚RGK蛋白是否受鸟嘌呤核苷酸结合调控的方式是否符合规范的G蛋白调控范式。我们利用策略性Rad和Rem突变体以及异源细胞和心肌细胞中的一系列功能读数（CaV1.2电流，Ca ^{2 + 瞬变，CaVβ结合）来确定是否这些RGK蛋白以规范的方式调节。我们的研究结果表明，就其鸟嘌呤核苷酸结合域在CaV1.2通道调节中的调节作用而言，Rad和Rem是非经典G蛋白。我们的发现为控制RGK调节和功能的细胞机制提供了更深刻的见解，并有助于我们了解其病理生理作用。}

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期刊名称 The Journal of Physiology
作者
Donald D. Chang; Henry M. Colecraft;
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年(卷),期 2015(593),23
年度 2015
页码 5075–5090
总页数 16
原文格式 PDF
正文语种
中图分类神经科学;人体生理学;
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1. Rad and Rem are non-canonical G-proteins with respect to the regulatory role of guanine nucleotide binding in Ca(V)1.2 channel regulation [J] . Chang Donald D., Colecraft Henry M. The Journal of Physiology . 2015,第23期

机译：Rad和Rem是鸟嘌呤核苷酸结合在Ca（V）1.2通道调节中的调节作用方面的非规范性G蛋白
2. Guanine nucleotide regulation of [3H]vasopressin binding to liver plasma membranes and solubilized receptors Evidence for the involvement of a guanine nucleotide regulatory protein [J] . D Bojanic, J N Fain The biochemical journal . 1986,第2期

机译：鸟嘌呤核苷酸调节[3H]加压素与肝细胞膜和可溶受体的结合鸟嘌呤核苷酸调节蛋白参与的证据
3. Cytosolic Na~+ controls an epithelial Na~+ channel via the Go guanine nucleotide-binding regulatory protein [J] . P. Komwatana, A. Dinudom, J. A. Young Proceedings of the National Academy of Sciences of the United States of America . 1996,第15期

机译：胞质Na〜+通过Go鸟嘌呤核苷酸结合调节蛋白控制上皮Na〜+通道
4. rSNP_Guide: Meta-Tools Predicting of Regulatory DNA Signals Damaged/Appeared Due to Single Nucleotide Mutation by Alterations in Pattern of DNA Binding to Nuclear Proteins [C] . Mikhail Ponomarenko, Tatyana Merkulova, Julia Ponomarenko, International NAISO(Natural amp; Artificial Intelligence Systems Organization) Congress on Information Science Innovations Mar 17-21, 2001 Dubai, U.A.E. . 2001

机译：rSNP_Guide：预测由于单核苷酸突变导致DNA结合核蛋白模式改变而破坏/显示的调控DNA信号的元工具
5. Conformational and molecular modeling studies of the cholecystokinin-1 and -2 guanine nucleotide-binding regulatory protein-coupled receptors. [D] . Giragossian, Craig. 2003

机译：胆囊收缩素-1和-2鸟嘌呤核苷酸结合调节蛋白偶联受体的构象和分子建模研究。
6. Guanine nucleotide regulation of 3Hvasopressin binding to liver plasma membranes and solubilized receptors. Evidence for the involvement of a guanine nucleotide regulatory protein. [O] . D Bojanic, J N Fain 1986

机译：鸟嘌呤核苷酸调节3H加压素与肝质膜和可溶受体的结合。鸟嘌呤核苷酸调节蛋白参与的证据。
7. Guanine nucleotide regulation of [3H]vasopressin binding to liver plasma membranes and solubilized receptors. Evidence for the involvement of a guanine nucleotide regulatory protein. [O] . Bojanic, D, Fain, J N 1986

机译：鸟嘌呤核苷酸调节[3H]加压素与肝质膜和可溶受体的结合。鸟嘌呤核苷酸调节蛋白参与的证据。
8. Guanine Nucleotide-Binding Protein Participates in IgE Receptor-MediatedActivation of Endogenous and Reconstituted Phospholipase A2 in a Permeabilized Cell System [R] . Narasimhan, V., Holowka, D., Baird, B. 1990

机译：鸟嘌呤核苷酸结合蛋白参与IgE受体介导的内源性和重组磷脂酶a2在透化细胞系统中的活化

Rad and Rem are non‐canonical G‐proteins with respect to the regulatory role of guanine nucleotide binding in CaV1.2 channel regulation

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