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Serum and urine concentrations of morphine and morphine metabolites in patients with advanced cancer receiving continuous intravenous morphine: an observational study

机译：连续静脉注射吗啡对晚期癌症患者血清和尿液中吗啡及吗啡代谢产物的浓度：一项观察性研究

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摘要

BackgroundThe feasibility and clinical implication of drug monitoring of morphine, morphine-6-glucuronide (M6G) and morphine-3-glucuronide (M3G) need further investigation. This study aimed to determine what predicts serum concentrations of morphine in cancer patients receiving continuously intravenous morphine, the relationships between serum concentration of morphine/its metabolites and urinary concentrations, and the relation between morphine concentrations and with clinical outcomes.

机译：背景：吗啡，吗啡6-葡萄糖醛酸（M6G）和吗啡-3-葡萄糖醛酸（M3G）的药物监测的可行性和临床意义需要进一步研究。这项研究的目的是确定预测连续静脉注射吗啡的癌症患者的吗啡血清浓度，吗啡及其代谢产物的血清浓度与尿液浓度之间的关系，以及吗啡浓度与临床结局之间的关系。

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期刊名称 BMC Palliative Care
作者
Yong Joo Lee; Sang-Yeon Suh; Junghan Song; Sanghee Shiny Lee; Ah-Ram Seo; Hong-Yup Ahn; Myung Ah Lee; Chul-Min Kim; Pål Klepstad;
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作者单位

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年(卷),期 2015(14),-1
年度 2015
页码 53
总页数 6
原文格式 PDF
正文语种
中图分类
关键词
Morphine Metabolite Serum Urine Monitoring Advanced cancer;

机译：吗啡;代谢物;血清;尿液;监测;晚期癌症;

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专利

1. Serum and urine concentrations of morphine and morphine metabolites in patients with advanced cancer receiving continuous intravenous morphine: an observational study [J] . Yong J Lee, Sang-Yeon Suh, Junghan Song, BMC Palliative Care . 2015,第1期

机译：连续静脉注射吗啡对晚期癌症患者血清和尿液中吗啡及吗啡代谢产物的浓度：一项观察性研究
2. Concentrations of morphine and morphine metabolites in CSF and plasma during continuous subcutaneous morphine administration in cancer pain patients. [J] . Wolff T, Samuelsson H, Hedner T Pain. . 1996,第2a3期

机译：癌症疼痛患者连续皮下注射吗啡期间脑脊液和血浆中吗啡和吗啡代谢物的浓度。
3. Start of oral morphine to cancer patients: effective serum morphine concentrations and contribution from morphine-6-glucuronide to the analgesia produced by morphine. [J] . Klepstad P, Kaasa S, Borchgrevink PC European journal of clinical pharmacology . 2000,第10期

机译：向癌症患者开始口服吗啡：有效的血清吗啡浓度以及吗啡-6-葡糖醛酸对吗啡产生的镇痛作用的作用。
4. Determination of Morphine and Its Metabolites Morphine 3-Glucuronide and Morphine 6-Glucuronide in Human Plasma by LC-MS/MS [C] . Vivek Tummala, Sherwin Jiang, Robert Harman, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2009

机译：通过LC-MS / MS测定吗啡及其代谢物吗啡3-葡糖苷和吗啡6-葡糖醛酸酯
5. Integration of Morphine and Virtual Reality: Pain Management for Adult Hospice Cancer Patients [D] . Hurd, Arlisa. 2022

机译：吗啡和虚拟现实的整合：成人临终关系癌症患者的疼痛管理
6. Day-to-day variations during clinical drug monitoring of morphine morphine-3-glucuronide and morphine-6-glucuronide serum concentrations in cancer patients. A prospective observational study [O] . Pål Klepstad, Priscilla Hilton, Jorunn Moen, 2004

机译：癌症患者中吗啡吗啡-3-葡糖醛酸和吗啡-6-葡糖醛酸血清浓度的临床药物监测期间的每日变化。前瞻性观察研究
7. Serum and urine concentrations of morphine and morphine metabolites in patients with advanced cancer receiving continuous intravenous morphine: an observational study [O] . Yong Joo Lee, Sang-Yeon Suh, Junghan Song, 2015

机译：连续静脉注射吗啡对晚期癌症患者血清和尿液中吗啡及吗啡代谢产物的浓度：一项观察性研究

Serum and urine concentrations of morphine and morphine metabolites in patients with advanced cancer receiving continuous intravenous morphine: an observational study

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