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New Knowledge from Old: In silico discovery of novel protein domains in Streptomyces coelicolor

机译：来自旧的新知识：在计算机上发现天蓝色链霉菌中新蛋白结构域的知识

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BackgroundStreptomyces coelicolor has long been considered a remarkable bacterium with a complex life-cycle, ubiquitous environmental distribution, linear chromosomes and plasmids, and a huge range of pharmaceutically useful secondary metabolites. Completion of the genome sequence demonstrated that this diversity carried through to the genetic level, with over 7000 genes identified. We sought to expand our understanding of this organism at the molecular level through identification and annotation of novel protein domains. Protein domains are the evolutionary conserved units from which proteins are formed.

机译：背景长期以来，腔肠链霉菌一直被认为是一种杰出的细菌，具有复杂的生命周期，无处不在的环境分布，线性染色体和质粒以及大量可药用的次级代谢产物。基因组序列的完成表明，这种多样性一直延续到遗传水平，已鉴定出7000多个基因。我们试图通过鉴定和注释新的蛋白质结构域在分子水平上扩大对这种生物的理解。蛋白质结构域是形成蛋白质的进化保守单位。

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期刊名称 BMC Microbiology
作者
Corin Yeats; Stephen Bentley; Alex Bateman;
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年(卷),期 2003(3),-1
年度 2003
页码 3
总页数 20
原文格式 PDF
正文语种
中图分类微生物学;
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1. New Knowledge from Old: In silico discovery of novel protein domains in Streptomyces coelicolor [J] . Corin Yeats, Stephen Bentley, Alex Bateman BMC Microbiology . 2003,第1期

机译：来自旧的新知识：在计算机上发现天蓝色链霉菌中的新蛋白质结构域
2. The bldC Developmental Locus of Streptomyces coelicolor Encodes a Member of a Family of Small DNA-Binding Proteins Related to the DNA-Binding Domains of the MerR Family [J] . Alison C. Hunt, Luis Servín-González, Gabriella H. Kelemen, Journal of bacteriology . 2005,第2期

机译：coelicolor链霉菌的bldC发育轨迹编码与MerR家族的DNA结合域相关的小DNA结合蛋白家族的成员。
3. The Streptomyces coelicolor Lipoate-protein Ligase Is a Circularly Permuted Version of the Escherichia coli Enzyme Composed of Discrete Interacting Domains [J] . Xinyun Cao, John Cronan The Journal of biological chemistry . 2015,第11期

机译：链霉菌的脂质溶胶蛋白连接酶是由离散相互作用域组成的大肠杆菌酶的圆形置换版本
4. Integrated Metabolomics Approach Enables Discovery of Novel Natural Products from Streptomyces coelicolor A3(2) [C] . Ashley M. Sidebottom, Andrew R. Johnson, Erin E. Carlson American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：综合的代谢组种方法可以发现来自链霉菌的新型天然产物来自链霉菌的Coelicolor A3（2）
5. Characterization of the carboxyltransferase domain in acyl -CoA carboxylase (ACCase) from Streptomyces coelicolor and Mycobacterium tuberculosis. [D] . Lin, Ting-Wan. 2006

机译：表征Coelicolor链霉菌和结核分枝杆菌的酰基-CoA羧化酶（ACCase）中的羧基转移酶结构域。
6. The bldC Developmental Locus of Streptomyces coelicolor Encodes a Member of a Family of Small DNA-Binding Proteins Related to the DNA-Binding Domains of the MerR Family [O] . Alison C. Hunt, Luis Servín-González, Gabriella H. Kelemen, 2005

机译：coelicolor链霉菌的bldC发育轨迹编码与MerR家族的DNA结合域相关的小DNA结合蛋白家族的成员。
7. New Knowledge from Old: In silico discovery of novel protein domains in Streptomyces coelicolor [O] . Yeats Corin, Bentley Stephen, Bateman Alex 2003

机译：来自旧的新知识：在计算机上发现天蓝色链霉菌中新蛋白结构域的知识

New Knowledge from Old: In silico discovery of novel protein domains in Streptomyces coelicolor

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