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Deregulation of phytoene-β-carotene synthase results in derepression of astaxanthin synthesis at high glucose concentration in Phaffia rhodozyma astaxanthin-overproducing strain MK19

机译：在高葡萄糖浓度的红发夫夫病虾青素生产过量菌株MK19中植物六烯-β-胡萝卜素合酶的失控导致虾青素合成的抑制。

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BackgroundA major obstacle to industrial-scale astaxanthin production by the yeast Phaffia rhodozyma is the strong inhibitory effect of high glucose concentration on astaxanthin synthesis. We investigated, for the first time, the mechanism of the regulatory effect of high glucose (> 100 g/L) at the metabolite and transcription levels.

机译：背景酵母酵母红发夫夫酵母在工业规模上生产虾青素的主要障碍是高葡萄糖浓度对虾青素合成的强烈抑制作用。我们首次研究了高葡萄糖（> 100 g / L）在代谢产物和转录水平上的调节作用机理。

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期刊名称 BMC Microbiology
作者
Lili Miao; Shuang Chi; Mengru Wu; Zhipei Liu; Ying Li;
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作者单位

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年(卷),期 2019(19),-1
年度 2019
页码 133
总页数 11
原文格式 PDF
正文语种
中图分类微生物学;
关键词
Phaffia rhodozyma Glucose metabolism Astaxanthin Phytoene-β-carotene synthase Gene expression;

机译：红发夫酵母;葡萄糖代谢;虾青素;并茂-β-胡萝卜素合酶;基因表达;

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专利

1. Evolutionary engineering of Phaffia rhodozyma for astaxanthin-overproducing strain [J] . Jixian GONG, Nan DUAN, Xueming ZHAO 化学科学与工程前沿：英文版 . 2012,第002期

机译：红发夫夫酵母对虾青素高产菌株的进化工程
2. Gamma irradiation as a useful tool for the isolation of astaxanthin-overproducing mutant strains of Phaffia rhodozyma. [J] . Najafi N, Ahmadi AR, Hosseini R, Canadian journal of microbiology . 2011,第9期

机译：伽马射线辐照作为分离虾红素高产红发夫酵母突变体菌株的有用工具。
3. Cloning of the astaxanthin synthase gene from Xanthophyllomyces dendrorhous (Phaffia rhodozyma) and its assignment as a beta-carotene 3-hydroxylase/4-ketolase. [J] . Ojima K, Breitenbach J, Visser H, Molecular biology reports . 2006,第2期

机译：克隆来自黄腐叶黄腐菌（红发夫）的虾青素合酶基因，并将其指定为β-胡萝卜素3-羟化酶/ 4-酮醇酶。
4. Optimization of medium composition for astaxanthin biosynthesis and cell growth by Phaffia rhodozyma using response surface methodology [C] . Xuechao Xia, Cairong Xu, Chuanhe Zhu International Conference on Human Health and Medical Engineering. . 2014

机译：用响应面法测定亚克斯坦蛋白生物合成和细胞生长的培养基组合物优化
5. The antioxidant role of astaxanthin and its biosynthesis in the yeast Phaffia rhodozyma. [D] . Schroeder, William Andrew. 1996

机译：虾青素的抗氧化作用及其在酵母红发夫酵母中的生物合成。
6. Selection of Astaxanthin-Overproducing Mutants of Phaffia rhodozyma with β-Ionone [O] . M. J. Lewis, N. Ragot, M. C. Berlant, 1990

机译：β-紫罗兰酮筛选红景天虾青素高产突变体
7. Deregulation of phytoene-β-carotene synthase results in derepression of astaxanthin synthesis at high glucose concentration in Phaffia rhodozyma astaxanthin-overproducing strain MK19 [O] . Lili Miao, Shuang Chi, Mengru Wu, 2019

机译：植物 - β-胡萝卜素合酶的放松管制导致在腓酰蛋糖核虾仁蛋白酶上过氧化菌菌菌株的高葡萄糖浓度下对虾青素合成的DERAPLING

Deregulation of phytoene-β-carotene synthase results in derepression of astaxanthin synthesis at high glucose concentration in Phaffia rhodozyma astaxanthin-overproducing strain MK19

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