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Is blood pressure reduction a valid surrogate endpoint for stroke prevention? an analysis incorporating a systematic review of randomised controlled trials a by-trial weighted errors-in-variables regression the surrogate threshold effect (STE) and the biomarker-surrogacy (BioSurrogate) evaluation schema (BSES)

机译：降压是否是预防中风的有效替代指标？一项分析包括对随机对照试验的系统评价试验加权加权变量误差回归替代阈值效应（STE）和生物标志物替代（BioSurrogate）评估方案（BSES）

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BackgroundBlood pressure is considered to be a leading example of a valid surrogate endpoint. The aims of this study were to (i) formally evaluate systolic and diastolic blood pressure reduction as a surrogate endpoint for stroke prevention and (ii) determine what blood pressure reduction would predict a stroke benefit.

机译：背景血压被认为是有效替代终点的主要示例。这项研究的目的是（i）正式评估收缩压和舒张压的降低，作为中风预防的替代终点；以及（ii）确定哪些降压可以预测中风的益处。

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期刊名称 BMC Medical Research Methodology
作者
Marissa N Lassere; Kent R Johnson; Michal Schiff; David Rees;
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作者单位

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年(卷),期 2012(12),-1
年度 2012
页码 27
总页数 21
原文格式 PDF
正文语种
中图分类医院、综合医院;中医院;
关键词
Blood pressure Stroke Surrogate Endpoint Biomarker;

机译：血压;中风;替代终点;生物标志物;

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外文文献

1. Is blood pressure reduction a valid surrogate endpoint for stroke prevention? an analysis incorporating a systematic review of randomised controlled trials, a by-trial weighted errors-in-variables regression, the surrogate threshold effect (STE) and the biomarker-surrogacy (BioSurrogate) evaluation schema (BSES) [J] . Marissa N Lassere, Kent R Johnson, Michal Schiff, BMC Medical Research Methodology . 2012,第1期

机译：降低血压是否是预防中风的有效替代指标？一项分析包括对随机对照试验的系统评价，按试验进行的加权变量误差回归，替代阈值效应（STE）和生物标志物替代（BioSurrogate）评估方案（BSES）
2. Optimized Image-Based Surrogate Endpoints in Targeted Therapies for Glioblastoma: A Systematic Review and Meta-Analysis of Phase III Randomized Controlled Trials [J] . Suh Chong Hyun, Kim Ho Sung, Jung Seung Chai, Korean journal of radiology : . 2020,第4期

机译：胶质母细胞瘤的有针对性疗法的优化的基于图像的代理终点：系统评价和阶段分析III期随机对照试验
3. An evaluation of the feasibility, cost and value of information of a multicentre randomised controlled trial of intravenous immunoglobulin for sepsis (severe sepsis and septic shock): Incorporating a systematic review, metaanalysis and value of information analysis [J] . Health technology assessment: HTA . 2012,第7期

机译：评估败血症（严重脓毒症和败血性休克）静脉免疫球蛋白的多中心随机对照试验的信息的可行性，成本和价值：纳入系统的综述，荟萃分析和信息分析的价值
4. Lowering blood pressure after acute intracerebral haemorrhage: protocol for a systematic review and meta-analysis using individual patient data from randomised controlled trials participating in the Blood Pressure in Acute Stroke Collaboration (BASC) [O] . Tom J Moullaali, Xia Wang, Lisa J Woodhouse, 2019

机译：急性脑出血后降低血压：使用参与急性卒中血压（BASC）的随机对照试验中的个体患者数据进行系统回顾和荟萃分析的方案
5. Is blood pressure reduction a valid surrogate endpoint for stroke prevention? an analysis incorporating a systematic review of randomised controlled trials, a by-trial weighted errors-in-variables regression, the surrogate threshold effect (STE) and the biomarker-surrogacy (BioSurrogate) evaluation schema (BSES) [O] . Marissa N Lassere, Kent R Johnson, Michal Schiff, 2012

机译：降压是否是预防中风的有效替代指标？一项分析包括对随机对照试验的系统评价，试验加权加权变量误差回归，替代阈值效应（STE）和生物标志物替代（BioSurrogate）评估方案（BSES）

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