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Effect of methylene blue on the genomic response to reperfusion injury induced by cardiac arrest and cardiopulmonary resuscitation in porcine brain

机译：亚甲蓝对猪心跳骤停和心肺复苏引起的再灌注损伤基因组反应的影响

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BackgroundCerebral ischemia/reperfusion injury is a common secondary effect of cardiac arrest which is largely responsible for postresuscitative mortality. Therefore development of therapies which restore and protect the brain function after cardiac arrest is essential. Methylene blue (MB) has been experimentally proven neuroprotective in a porcine model of global ischemia-reperfusion in experimental cardiac arrest. However, no comprehensive analyses have been conducted at gene expression level.

机译：背景脑缺血/再灌注损伤是心脏骤停的常见继发效应，这主要是复苏后的死亡率。因此，开发在心脏骤停后恢复和保护脑功能的疗法至关重要。亚甲蓝（MB）在实验性心脏骤停的整体缺血-再灌注猪模型中已被实验证明具有神经保护作用。但是，尚未在基因表达水平上进行全面分析。

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期刊名称 BMC Medical Genomics
作者
Cécile Martijn; Lars Wiklund;
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年(卷),期 2010(3),-1
年度 2010
页码 27
总页数 19
原文格式 PDF
正文语种
中图分类遗传学;
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专利

1. Effect of methylene blue on the genomic response to reperfusion injury induced by cardiac arrest and cardiopulmonary resuscitation in porcine brain [J] . Cécile Martijn, Lars Wiklund BMC Medical Genomics . 2010,第1期

机译：亚甲蓝对猪心跳骤停和心肺复苏所致再灌注损伤基因组反应的影响
2. Cerebral Tissue Oxidative Ischemia-Reperfusion Injury in Connection with Experimental Cardiac Arrest and Cardiopulmonary Resuscitation: Effect of Mild Hypothermia and Methylene Blue [J] . Wiklund Lars, Patnaik Ranjana, Sharma Aruna, Molecular Neurobiology . 2018,第1期

机译：脑组织氧化缺血再灌注损伤与实验心脏骤停和心肺复苏相关：轻度低温和亚甲基蓝的作用
3. Effects of hypothermia on brain injury assessed by magnetic resonance imaging after cardiopulmonary resuscitation in a porcine model of cardiac arrest [J] . TangZ.-R., LiC.-S., ZhaoH., The American journal of emergency medicine . 2013,第1期

机译：在心脏骤停的猪模型中，通过心肺复苏后磁共振成像评估低温对脑损伤的影响
4. Quantitative assessment of brain tissue oxygenation in porcine models of cardiac arrest and cardiopulmonary resuscitation using hyperspectral near-infrared spectroscopy [C] . Shahin S. Lotfabadi, Vladislav Toronov, Andrew Ramadeen, Conference on Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics . 2014

机译：使用高光谱近红外光谱法定量评估心搏停止和心肺复苏的猪模型中脑组织氧合
5. Head and Thorax Elevation During Active Compression Decompression Cardiopulmonary Resuscitation with an Impedance Threshold Device Improves Cerebral Perfusion in a Swine Model of Prolonged Cardiac Arrest [D] . Moore, Johanna Catherine. 2017

机译：主动压缩减压期间的头部和胸部升高，具有阻抗阈值装置的心肺重新刺架改善了延长心脏骤停的猪模型中的脑灌注
6. Cerebral Tissue Oxidative Ischemia-Reperfusion Injury in Connection with Experimental Cardiac Arrest and Cardiopulmonary Resuscitation: Effect of Mild Hypothermia and Methylene Blue [O] . Lars Wiklund, Ranjana Patnaik, Aruna Sharma, -1

机译：与实验性心脏骤停和心肺复苏相关的脑组织氧化性缺血再灌注损伤：亚低温和亚甲基蓝的影响
7. Effect of methylene blue on the genomic response to reperfusion injury induced by cardiac arrest and cardiopulmonary resuscitation in porcine brain [O] . Cécile Martijn, Lars Wiklund 2010

机译：亚甲蓝对猪心跳骤停和心肺复苏引起的再灌注损伤基因组反应的影响

Effect of methylene blue on the genomic response to reperfusion injury induced by cardiac arrest and cardiopulmonary resuscitation in porcine brain

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