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DNA methylation changes in ovarian cancer are cumulative with disease progression and identify tumor stage

机译：卵巢癌中的DNA甲基化变化随疾病进展而累积并确定肿瘤分期

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摘要

BackgroundHypermethylation of promoter CpG islands with associated loss of gene expression, and hypomethylation of CpG-rich repetitive elements that may destabilize the genome are common events in most, if not all, epithelial cancers.

机译：背景在大多数（如果不是全部）上皮癌中，启动子CpG岛的超甲基化以及相关的基因表达损失以及富含CpG的重复元件的低甲基化可能破坏基因组，这是常见的事件。

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期刊名称 BMC Medical Genomics
作者
George S Watts; Bernard W Futscher; Nicholas Holtan; Koen DeGeest; Frederick E Domann; Stephen L Rose;
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作者单位

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年(卷),期 2008(1),-1
年度 2008
页码 47
总页数 12
原文格式 PDF
正文语种
中图分类遗传学;
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专利

1. DNA methylation changes in ovarian cancer are cumulative with disease progression and identify tumor stage [J] . George S Watts, Bernard W Futscher, Nicholas Holtan, BMC Medical Genomics . 2008,第1期

机译：卵巢癌中的DNA甲基化变化随疾病进展而累积并确定肿瘤阶段
2. Global methylation profiling in serous ovarian cancer is indicative for distinct aberrant DNA methylation signatures associated with tumor aggressiveness and disease progression [J] . KeitaM., WangZ.-Q., PelletierJ.-F., Gynecologic Oncology: An International Journal . 2013,第2期

机译：浆液性卵巢癌中的总体甲基化图谱表明与肿瘤侵袭性和疾病进展相关的独特的异常DNA甲基化特征
3. Global methylation profiling in serous ovarian cancer is indicative for distinct aberrant DNA methylation signatures associated with tumor aggressiveness and disease progression [J] . KeitaM., WangZ.-Q., PelletierJ.-F., Gynecologic Oncology: An International Journal . 2013,第2期

机译：在浆液癌中的全球甲基化分析表明与肿瘤侵袭性和疾病进展相关的明显异常DNA甲基化签名
4. Utilize Imputation Method and Meta-analysis to Identify DNA-Methylation-Mediated microRNAs in Ovarian Cancer [C] . Ezra B. Wijaya, Erwandy Lim, David Agustriawan, International conference on algorithms for computational biology . 2018

机译：利用归因法和荟萃分析鉴定卵巢癌中DNA甲基化介导的microRNA。
5. The development of intratumoral heterogeneity in ovarian tumors: Role of cancer stem cells in disease progression. [D] . Lunsford, Elaine P. 2014

机译：卵巢肿瘤内肿瘤异质性的发展：癌症干细胞在疾病进展中的作用。
6. DNA hypomethylation-mediated activation of Cancer/Testis Antigen 45 (CT45) genes is associated with disease progression and reduced survival in epithelial ovarian cancer [O] . Wa Zhang, Carter J Barger, Petra A Link, 2015

机译：DNA低甲基化介导的癌症/睾丸抗原45（CT45）基因激活与上皮性卵巢癌的疾病进展和存活率降低相关
7. DNA methylation changes in ovarian cancer are cumulative with disease progression and identify tumor stage [O] . 2008

机译：卵巢癌中的DNA甲基化变化随疾病进展而累积并确定肿瘤分期
8. Role of DNA Methylation in Altering Gene Expression During the Early Stages of Human Breast Cancer Progression in the MCF10AT Xenograft Model [R] . Christman, J. K. 2004

机译：DNa甲基化在mCF10aT异种移植模型人乳腺癌早期阶段改变基因表达中的作用

DNA methylation changes in ovarian cancer are cumulative with disease progression and identify tumor stage

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