Integrated molecular portrait of non-small cell lung cancers

机译：非小细胞肺癌的综合分子画像

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摘要

BackgroundNon-small cell lung cancer (NSCLC), a leading cause of cancer deaths, represents a heterogeneous group of neoplasms, mostly comprising squamous cell carcinoma (SCC), adenocarcinoma (AC) and large-cell carcinoma (LCC). The objectives of this study were to utilize integrated genomic data including copy-number alteration, mRNA, microRNA expression and candidate-gene full sequencing data to characterize the molecular distinctions between AC and SCC.

机译：背景非小细胞肺癌（NSCLC）是导致癌症死亡的主要原因，它代表了一组异质性肿瘤，主要包括鳞状细胞癌（SCC），腺癌（AC）和大细胞癌（LCC）。这项研究的目的是利用整合的基因组数据，包括拷贝数变化，mRNA，microRNA表达和候选基因全测序数据来表征AC和SCC之间的分子差异。

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期刊名称 BMC Medical Genomics
作者
Vladimir Lazar; Chen Suo; Cedric Orear; Joost van den Oord; Zsofia Balogh; Justine Guegan; Bastien Job; Guillaume Meurice; Hugues Ripoche; Stefano Calza; Johanna Hasmats; Joakim Lundeberg; Ludovic Lacroix; Philippe Vielh; Fabienne Dufour; Janne Lehtiö; Rudolf Napieralski; Alexander Eggermont; Manfred Schmitt; Jacques Cadranel; Benjamin Besse; Philippe Girard; Fiona Blackhall; Pierre Validire; Jean-Charles Soria; Philippe Dessen; Johan Hansson; Yudi Pawitan;
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作者单位

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年(卷),期 2013(6),-1
年度 2013
页码 53
总页数 12
原文格式 PDF
正文语种
中图分类遗传学;
关键词
NSCLC AC SCC LCC Systems biology;

机译：NSCLC;AC;SCC;LCC;系统生物学;

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专利

1. Integrated molecular portrait of non-small cell lung cancers [J] . Vladimir Lazar, Chen Suo, Cedric Orear, BMC Medical Genomics . 2013,第1期

机译：非小细胞肺癌的综合分子画像
2. P3.05-006 Integrated Genomic Analysis to Assess the Molecular Signature of Japanese Patients with Non-Small Cell Lung Cancer [J] . M. Isaka, M. Serizawa, T. Nagashima, Journal of thoracic oncology: official publication of the International Association for the Study of Lung Cancer . 2017,第11期

机译：P3.05-006综合基因组分析评估日本非小细胞肺癌患者的分子签名
3. Molecular staging of lung cancer: real-time polymerase chain reaction estimation of lymph node micrometastatic tumor cell burden in stage I non-small cell lung cancer--preliminary results of Cancer and Leukemia Group B Trial 9761. [J] . DCunha Jonathan, Corfits AngelaL, Herndon JamesE 2nd, The Journal of Thoracic and Cardiovascular Surgery . 2002,第3期

机译：肺癌的分子分期：I期非小细胞肺癌淋巴结微转移肿瘤细胞负荷的实时聚合酶链反应估计-癌症和白血病B组试验9761的初步结果。
4. Exploring the Molecular Determinants of Tumor-Stroma Interaction in Non-small Cell Lung Cancer Through the Utilization of RNA-seq Data from Lung Biopsies [C] . G. Kontogianni, O. Papadodima, A. Mitrakas Mediterranean Conference on Medical and Biological Engineering and Computin . 2016

机译：通过利用来自肺活组织检查的RNA-SEQ数据探索非小细胞肺癌中肿瘤基质相互作用的分子决定因素
5. The cost effectiveness of screening for early stage lung cancer and the testing and treatment of molecular subgroups among non-small cell lung cancer patients in the province of ontario, canada [D] . Thao, Mallory. 2014

机译：加拿大安大略省非小细胞肺癌患者早期肺癌筛查的成本效益及分子亚群的检测和治疗
6. Cancer-associated fibroblasts promote non-small cell lung cancer cell invasion by upregulation of glucose-regulated protein 78 (GRP78) expression in an integrated bionic microfluidic device [O] . Ting Yu, Zhe Guo, Hui Fan, 2016

机译：癌症相关的成纤维细胞通过上调仿生微流控设备中葡萄糖调节蛋白78（GRP78）的表达来促进非小细胞肺癌细胞的侵袭
7. Integrated molecular portrait of non-small cell lung cancers [O] . Vladimir Lazar, Chen Suo, Cedric Orear, 2013

机译：非小细胞肺癌的综合分子画像

Integrated molecular portrait of non-small cell lung cancers

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