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Metabolic changes in type 2 diabetes are reflected in peripheral blood cells revealing aberrant cytotoxicity a viral signature and hypoxia inducible factor activity

机译：2型糖尿病的代谢变化反映在外周血细胞中显示出异常的细胞毒性病毒信号和低氧诱导因子活性

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BackgroundMetabolic syndrome (MetS) is characterized by central obesity, insulin resistance, dysglycemia, and a pro-atherogenic plasma lipid profile. MetS creates a high risk for development of type 2 diabetes (T2DM) and cardiovascular disease (CVD), presumably by altering inflammatory responses. Presently, it is unknown how the chronic metabolic disturbances in acute hyperglycemia, MetS and T2DM affect the immune activity of peripheral blood cells.

机译：背景代谢综合征（MetS）的特征在于中枢型肥胖，胰岛素抵抗，血糖异常和促动脉粥样硬化血浆脂质谱。 MetS可能通过改变炎症反应而导致2型糖尿病（T2DM）和心血管疾病（CVD）发生的高风险。目前，尚不清楚急性高血糖症，MetS和T2DM中的慢性代谢紊乱如何影响外周血细胞的免疫活性。

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期刊名称 BMC Medical Genomics
作者
Tineke C. T. M. van der Pouw Kraan; Weena J. Chen; Mathijs C. M. Bunck; Daniel H. van Raalte; Nynke J. van der Zijl; Renate E. van Genugten; Liselotte van Bloemendaal; Josefien M. Baggen; Erik H. Serné; Michaela Diamant; Anton J. G. Horrevoets;
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年(卷),期 2015(8),-1
年度 2015
页码 20
总页数 16
原文格式 PDF
正文语种
中图分类遗传学;
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1. Metabolic changes in type 2 diabetes are reflected in peripheral blood cells, revealing aberrant cytotoxicity, a viral signature, and hypoxia inducible factor activity [J] . Tineke C. T. M. van der Pouw Kraan, Weena J. Chen, Mathijs C. M. Bunck, BMC Medical Genomics . 2015,第1期

机译：2型糖尿病的代谢变化反映在外周血细胞中，显示出异常的细胞毒性，病毒信号和低氧诱导因子活性
2. Effect of redox status of peripheral blood on immune signature of circulating regulatory and cytotoxic T cells in streptozotocin induced rodent model of type I diabetes [J] . Anupam Kumari, Kaushal Jyotsana, Prabhakar Nirmal, Immunobiology: Zeitschrift fur Immunitatsforschung . 2018,第10期

机译：外周血氧化还原氧化还原对链脲佐菌素诱导型糖尿病啮齿失体模型中循环调节和细胞毒性T细胞的免疫特征
3. Type I interferon subtypes produced by human peripheral mononuclear cells from one normal donor stimulated by viral and non-viral inducing factors. [J] . Palmer P, Tovey MG, Raschilas F, European cytokine network . 2007,第2期

机译：由一名正常供体的人外周单核细胞在病毒和非病毒诱导因子的刺激下产生的I型干扰素亚型。
4. S-Nitrosoglutathione and Hypoxia-Inducible Factor-1 Confer Chemoresistance against Carbamoylating Cytotoxicity of BCNU in Rat C6 Glioma Cells [C] . DING-I YANG, SHANG-DER CHEN, JIU-HAW YIN, Asian Society for Mitochondrial Research and Medicine . 2005

机译：S-硝基吡咯肠和缺氧诱导因子-1赋予大鼠C6胶质瘤细胞中BCNU的碳酸化细胞毒性的化学抑制性
5. Hypoxia inducible factors: Redefining metabolic regulation of CD8 T cell differentiation and function [D] . Phan, Anthony. 2016

机译：缺氧诱导因素：重新定义CD8 T细胞分化和功能的代谢调节
6. Differential Expression of microRNAs in Peripheral Blood Mononuclear Cells Identifies Autophagy and TGF-Beta-Related Signatures Aberrantly Expressed in Inflammatory Bowel Disease [O] . Aylia Mohammadi, Orlaith B Kelly, Melissa Filice, -1

机译：microRNA在外周血单个核细胞中的差异表达可确定在炎性肠病中异常表达的自噬和TGF-β相关特征。
7. Metabolic changes in type 2 diabetes are reflected in peripheral blood cells, revealing aberrant cytotoxicity, a viral signature, and hypoxia inducible factor activity [O] . 2015

机译：2型糖尿病的代谢变化反映在外周血细胞中，显示出异常的细胞毒性，病毒信号和低氧诱导因子活性

Metabolic changes in type 2 diabetes are reflected in peripheral blood cells revealing aberrant cytotoxicity a viral signature and hypoxia inducible factor activity

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