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Blood-based identification of non-responders to anti-TNF therapy in rheumatoid arthritis

机译：类风湿关节炎抗TNF治疗无反应的基于血的鉴定

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摘要

BackgroundFaced with an increasing number of choices for biologic therapies, rheumatologists have a critical need for better tools to inform rheumatoid arthritis (RA) disease management. The ability to identify patients who are unlikely to respond to first-line biologic anti-TNF therapies prior to their treatment would allow these patients to seek alternative therapies, providing faster relief and avoiding complications of disease.

机译：背景技术面对越来越多的生物疗法选择，风湿病学家迫切需要更好的工具来告知类风湿关节炎（RA）疾病管理。能够在治疗前识别不太可能对一线生物抗TNF生物疗法产生反应的患者的能力将使这些患者能够寻求替代疗法，从而更快地缓解疾病并避免疾病并发症。

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期刊名称 BMC Medical Genomics
作者
Ty M. Thomson; Reynald M. Lescarbeau; David A. Drubin; Daphna Laifenfeld; David de Graaf; David A. Fryburg; Bruce Littman; Renée Deehan; Aaron Van Hooser;
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作者单位

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年(卷),期 2015(8),-1
年度 2015
页码 26
总页数 12
原文格式 PDF
正文语种
中图分类遗传学;
关键词
Rheumatoid arthritis Infliximab Anti-TNF therapy Classifier;

机译：类风湿关节炎;英夫利昔单抗;抗TNF治疗;分类器;

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专利

1. Blood-based identification of non-responders to anti-TNF therapy in rheumatoid arthritis [J] . Ty M. Thomson, Reynald M. Lescarbeau, David A. Drubin, BMC Medical Genomics . 2015,第1期

机译：类风湿关节炎抗TNF治疗无反应的基于血的鉴定
2. Defining response to TNF-inhibitors in rheumatoid arthritis: the negative impact of anti-TNF cycling and the need for a personalized medicine approach to identify primary non-responders [J] . Johnson Keith J., Sanchez Helia N., Schoenbrunner Nancy Clinical rheumatology . 2019,第11期

机译：定义对类风湿性关节炎中TNF抑制剂的反应：抗TNF循环的负面影响以及个性化医学方法的需求识别初级非响应者
3. A mixed treatment comparison of the efficacy of anti-TNF agents in rheumatoid arthritis for methotrexate non-responders demonstrates differences between treatments: a Bayesian approach. [J] . Schmitz S, Adams R, Walsh CD, Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research . 2012,第2期

机译：类风湿关节炎对甲氨蝶呤无反应者的抗TNF药物疗效的混合治疗比较表明，治疗之间存在差异：贝叶斯方法。
4. Low-dose glucocorticoid therapy in rheumatoid arthritis: an obligatory therapy [C] . Johannes W. J. Bijlsma, Marlies C. van der Goes, Jos N. Hoes, International Conference on the Neuroendocrine Immune Basis of the Rheumatic Diseases . 2010

机译：低剂量糖皮质激素治疗类风湿性关节炎：义务治疗
5. Vaccinia virus complement control protein ameliorates collagen induced arthritis: Potential implications for therapy of rheumatoid arthritis. [D] . Jha, Purushottam. 2003

机译：牛痘病毒补体控制蛋白可改善胶原蛋白诱发的关节炎：类风湿关节炎的治疗潜力。
6. Association of a complement receptor 1 gene variant with baseline erythrocyte sedimentation rate levels in patients starting anti-TNF therapy in a UK rheumatoid arthritis cohort: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort [O] . J Bluett, I Ibrahim, D Plant, -1

机译：英国风湿性关节炎队列中开始抗TNF治疗的患者中补体受体1基因变异与基线红细胞沉降率的关联：类风湿关节炎遗传学和基因组学研究辛迪加队列研究结果
7. Blood-based identification of non-responders to anti-TNF therapy in rheumatoid arthritis [O] . Ty M. Thomson, Reynald M. Lescarbeau, David A. Drubin, 2015

机译：类风湿关节炎抗TNF治疗无反应的基于血的鉴定

Blood-based identification of non-responders to anti-TNF therapy in rheumatoid arthritis

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