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Genome-wide DNA methylome reveals the dysfunction of intronic microRNAs in major psychosis

机译：全基因组DNA甲基化揭示重大精神病患者内含microRNA的功能异常

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摘要

BackgroundDNA methylation is thought to be extensively involved in the pathogenesis of many diseases, including major psychosis. However, most studies focus on DNA methylation alteration at promoters of protein-coding genes, despite the poor correlation between DNA methylation and gene expression.

机译：背景技术DNA甲基化被认为广泛参与包括严重精神病在内的许多疾病的发病机理。然而，尽管DNA甲基化与基因表达之间的相关性较弱，但大多数研究都集中在蛋白质编码基因启动子的DNA甲基化改变上。

著录项

期刊名称 BMC Medical Genomics
作者
Hongying Zhao; Jinyuan Xu; Lin Pang; Yunpeng Zhang; Huihui Fan; Ling Liu; Tingting Liu; Fulong Yu; Guanxiong Zhang; Yujia Lan; Jing Bai; Xia Li; Yun Xiao;
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作者单位

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年(卷),期 2015(8),-1
年度 2015
页码 62
总页数 12
原文格式 PDF
正文语种
中图分类遗传学;
关键词
Major psychosis MeDIP-seq RNA-seq DNA methylation miRNA;

机译：严重精神病;MeDIP序列;RNA序列;DNA甲基化;miRNA;

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专利

1. Genome-wide DNA methylome reveals the dysfunction of intronic microRNAs in major psychosis [J] . Hongying Zhao, Jinyuan Xu, Lin Pang, BMC Medical Genomics . 2015,第1期

机译：全基因组DNA甲基化揭示重大精神病患者内含microRNA的功能异常
2. Genome-wide DNA methylation analysis of articular chondrocytes reveals a cluster of osteoarthritic patients* -Genome-wide DNA methylation study of hip and knee cartilage reveals embryonic organ and skeletal system morphogenesis as major pathways involved in osteoarthritis- DNA Methylation in Osteoarthritis [J] . Agro Food Industry Hi-Tech . 2018,第1期

机译：关节性软骨细胞的基因组DNA甲基化分析揭示了髋关节和膝关节软骨的骨抑制患者群* -Genome-宽的DNA甲基化研究显示胚胎器官和骨骼系形态发生，作为骨关节炎中骨关节炎甲基化的主要途径
3. Genome-wide profiling of DNA methylome and transcriptome in peripheral blood monocytes for major depression: A Monozygotic Discordant Twin Study [J] . Yun Zhu, Eric Strachan, Emily Fowler, Translational psychiatry. . 2019,第1期

机译：DNA甲基杂物和转录组的基因组分析在整个抑郁症外周血单核细胞中：单义声称双胞胎研究
4. Genome-Wide Copy Number Profiling of Single Cells in S-Phase Reveals DNA-Replication Domains [C] . Niels Van der Aa, Jiqiu Cheng, Ligia Mateiu, Molecular Medicine TRI-CON. . 2014

机译：S阶段单细胞的基因组拷贝数分析显示DNA复制域
5. Novel connections between DNA replication, telomere homeostasis and the DNA damage response revealed by a genome-wide screen for TEL1/ATM interactions in Saccharomyces cerevisiae. [D] . Piening, Brian D. 2013

机译：DNA复制，端粒稳态与DNA损伤反应之间的新型联系通过酿酒酵母中TEL1 / ATM相互作用的全基因组筛选揭示。
6. Genome-wide profiling of DNA methylome and transcriptome in peripheral blood monocytes for major depression: A Monozygotic Discordant Twin Study [O] . Yun Zhu, Eric Strachan, Emily Fowler, 2019

机译：抑郁症患者外周血单核细胞中DNA甲基化和转录组的全基因组分布分析：单合子不一致双胞胎研究
7. Genome-wide DNA methylome reveals the dysfunction of intronic microRNAs in major psychosis [O] . Hongying Zhao, Jinyuan Xu, Lin Pang, 2015

机译：全基因组DNA甲基化揭示重大精神病患者内含microRNA的功能异常

Genome-wide DNA methylome reveals the dysfunction of intronic microRNAs in major psychosis

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