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MicroRNA involvement in mechanism of endogenous protection induced by fastigial nucleus stimulation based on deep sequencing and bioinformatics

机译:MicroRNA参与基于深层测序和生物信息学的小脑顶核刺激诱导的内源性保护机制

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摘要

BackgroundNeurogenic neuroprotection is a promising approach for treating patients with ischemic brain lesions. Fastigial nucleus stimulation (FNS) has been shown to reduce the tissue damage resulting from focal cerebral ischemia in the earlier studies. However, the mechanisms of neuroprotection induced by FNS remain unclear. MicroRNAs (miRNAs) are a newly discovered group of non-coding small RNA molecules that negatively regulate target gene expression and involved in the regulation of pathological process. To date, there is a lack of knowledge on the expression of miRNA in response to FNS. Thus, we study the regulation of miRNAs in the rat ischemic brain by the neuroprotection effect of FNS.
机译:背景神经源性神经保护是一种治疗缺血性脑损伤患者的有前途的方法。在较早的研究中,小脑顶核刺激(FNS)可以减少因局灶性脑缺血引起的组织损伤。但是,由FNS诱导的神经保护机制尚不清楚。微小RNA(miRNA)是一组新发现的非编码小RNA分子,它们负调控靶基因的表达并参与病理过程的调控。迄今为止,缺乏关于响应FNS的miRNA表达的知识。因此,我们通过FNS的神经保护作用研究了miRNA在大鼠缺血脑中的调控。

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