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Unearthing new genomic markers of drug response by improved measurement of discriminative power

机译:通过改进判别能力发掘新的药物反应基因组标记

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摘要

BackgroundOncology drugs are only effective in a small proportion of cancer patients. Our current ability to identify these responsive patients before treatment is still poor in most cases. Thus, there is a pressing need to discover response markers for marketed and research oncology drugs. Screening these drugs against a large panel of cancer cell lines has led to the discovery of new genomic markers of in vitro drug response. However, while the identification of such markers among thousands of candidate drug-gene associations in the data is error-prone, an appraisal of the effectiveness of such detection task is currently lacking.
机译:背景技术肿瘤学药物仅在小部分癌症患者中有效。在大多数情况下,我们目前在治疗之前识别这些反应性患者的能力仍然很差。因此,迫切需要发现市售和研究的肿瘤学药物的反应标记。针对一大批癌细胞系筛选这些药物导致发现了新的体外药物反应基因组标记。但是,尽管在数据中成千上万的候选药物基因关联中识别此类标记容易出错,但目前尚缺乏对此类检测任务有效性的评估。

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