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Endogenous Fms-like Tyrosine Kinase-3 Ligand levels are not altered in mice after a severe burn and infection

机译：严重烧伤和感染后内源性Fms样酪氨酸激酶3配体水平没有改变

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BackgroundFms-like tyrosine kinase-3 ligand (Flt3L) is a hemopoietic cytokine and dendritic cell (DC) growth factor that promotes the proliferation and differentiation of progenitor cells into DCs. We have previously found that treatment of severely burned mice with recombinant Flt3L significantly enhances DC production and bacterial clearance from infected burn wounds, and increases global immune cell activation and survival in response to a burn wound infection. These significant benefits of Flt3L treatment after burn injury have prompted the question of whether or not severe burn injury induces deficits in endogenous Flt3L levels that could affect DCs and subsequent responses to infection.

机译：背景Fms样酪氨酸激酶3配体（Flt3L）是造血细胞因子和树突状细胞（DC）生长因子，可促进祖细胞向DC的增殖和分化。先前我们已经发现，用重组Flt3L处理严重烧伤的小鼠可显着增强DC的产生和从感染烧伤创面清除细菌的能力，并增加整体免疫细胞的活化和对烧伤创面感染的存活率。烧伤后Flt3L治疗的这些显着优势提示了严重烧伤是否引起内源性Flt3L水平缺乏的问题，该缺陷会影响DC和随后的感染反应。

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期刊名称 BMC Immunology
作者
Julia K Bohannon; Weihua Cui; Tracy Toliver-Kinsky;
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年(卷),期 2009(10),-1
年度 2009
页码 47
总页数 8
原文格式 PDF
正文语种
中图分类免疫学;
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专利

1. Endogenous Fms-like Tyrosine Kinase-3 Ligand levels are not altered in mice after a severe burn and infection [J] . Julia K Bohannon, Weihua Cui, Tracy Toliver-Kinsky BMC Immunology . 2009,第1期

机译：严重烧伤和感染后，内源性Fms样酪氨酸激酶3配体水平没有改变
2. Enhancement of dendritic cell production by fms-like tyrosine kinase-3 ligand increases the resistance of mice to a burn wound infection. [J] . Toliver Kinsky TE, Cui W, Murphey ED, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2005,第1期

机译：fms样酪氨酸激酶3配体增强树突状细胞的产生增加了小鼠对烧伤感染的抵抗力。
3. Enhancement of Dendritic Cell Production by Fms-Like Tyrosine Kinase-3 Ligand Increases the Resistance of Mice to a Burn Wound Infection [J] . Tracy E. Toliver-Kinsky, Weihua Cui, Erle D. Murphey, The journal of immunology . 2005,第1期

机译：Fms样酪氨酸激酶3配体的树突状细胞生产的增强增加了小鼠对烧伤伤口感染的抵抗力。
4. PLACENTAL SOLUBLE FMS-LIKE TYROSINE KINASE 1 (SFLT1) IN PREECLAMPSIA COMPLICATED BY HIV INFECTION [C] . N. Govender, J. Moodley, T. Naicker Annual Conference of the Microscopy Society of Southern Africa . 2011

机译：胎盘可溶性FMS样酪氨酸激酶1（SFLT1）在艾滋病毒感染复杂化
5. Response of the acutely malnourished weanling mouse to endogenous murine FMS-like tyrosine kinase 3 ligand. [D] . Hillyer, Lyn M. 2008

机译：急性营养不良的断奶小鼠对内源性小鼠FMS样酪氨酸激酶3配体的反应。
6. Fms-like tyrosine kinase-3 ligand alters antigen-specific responses to infections after severe burn injury [O] . Julia Bohannon, Geping Fang, Weihua Cui, -1

机译：FMS样酪氨酸激酶-3配体改变抗原特异性对感染后的抗原损伤后的反应
7. Endogenous Fms-like Tyrosine Kinase-3 Ligand levels are not altered in mice after a severe burn and infection [O] . Julia K Bohannon, Weihua Cui, Tracy Toliver-Kinsky 2009

机译：严重烧伤和感染后，内源性Fms样酪氨酸激酶3配体水平没有改变

Endogenous Fms-like Tyrosine Kinase-3 Ligand levels are not altered in mice after a severe burn and infection

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