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Cytotoxic function of CD8+ T lymphocytes isolated from patients with acute severe cerebral infarction: an assessment of stroke-induced immunosuppression

机译：急性重症脑梗死患者CD8 + T淋巴细胞的细胞毒性功能：中风诱导的免疫抑制评估

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BackgroundThere is increasing evidence on complex interaction between the nervous and immune systems in patients with cerebral infarction. This study was conducted to evaluate cytotoxic function of CD8⁺ T lymphocytes isolated from patients with acute severe cerebral infarction. In order to determine role of immune system in stroke, peripheral blood mononuclear cells (PBMCs) were taken and cytotoxic function of CD8⁺ T lymphocytes were induced by virus peptides and cells were analyzed on a four-color flow cytometer. Expression of CD107a, intracellular expression of interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α), and cell proliferation assay were analyzed by using carboxyl fluorescein diacetate succinimidyl ester (CFSE).

机译：背景越来越多的证据表明脑梗死患者的神经系统和免疫系统之间存在复杂的相互作用。本研究旨在评估急性重症脑梗死患者分离的CD8 ^{+ T淋巴细胞的细胞毒功能。为了确定免疫系统在中风中的作用，采集外周血单个核细胞（PBMC），并通过病毒肽诱导CD8 ^{+ T淋巴细胞的细胞毒性功能，并在四色流中分析细胞细胞仪。使用羧基荧光素二乙酸琥珀酰亚胺酯（CFSE）分析CD107a的表达，干扰素-γ（IFN-γ）和肿瘤坏死因子-α（TNF-α）的细胞内表达以及细胞增殖测定。}}

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期刊名称 BMC Immunology
作者
Gang Li; Xin Wang; Li-hong Huang; Yue Wang; Jun-jie Hao; Xia Ge; Xiao-yun Xu;
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作者单位

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年(卷),期 2013(14),-1
年度 2013
页码 1
总页数 7
原文格式 PDF
正文语种
中图分类免疫学;
关键词
CD8+ T lymphocytes Cerebral infarction Cytotoxic function;

机译：CD8 + T淋巴细胞;脑梗塞;细胞毒作用;

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专利

1. Cytotoxic function of CD8+ T lymphocytes isolated from patients with acute severe cerebral infarction: an assessment of stroke-induced immunosuppression [J] . Gang Li, Xin Wang, Li-hong Huang, BMC Immunology . 2013,第1期

机译：急性重症脑梗死患者CD8 + T淋巴细胞的细胞毒功能：中风诱导的免疫抑制评估
2. Hantavirus pulmonary syndrome: CD8+ and CD4+ cytotoxic T lymphocytes to epitopes on Sin Nombre virus nucleocapsid protein isolated during acute illness [J] . Ennis FA, Cruz J, Spiropoulou CF, Virology . 1997,第2期

机译：汉坦病毒性肺综合征：CD8 +和CD4 +细胞毒性T淋巴细胞在急性疾病期间分离出的Sin Nombre病毒核衣壳蛋白的表位
3. Human cytotoxic CD8+ T-lymphocyte clones engraft in severe combined immunodeficient (SCID) mice but show diminished function. [J] . de Kroon JF, van Bergen CA, de Paus RA, Journal of immunotherapy . 1997,第2期

机译：人细胞毒性CD8 + T淋巴细胞克隆植入严重的联合免疫缺陷（SCID）小鼠中，但功能减弱。
4. Association between neutrophil to lymphocyte ratio on admission and grace mortality risk score among acute myocardial infarction patient at BRSUD Tabanan in 2017 [C] . P G E A Suyasa Annual Applied Science and Engineering Conference . 2019

机译：2017年Brsud Tabanan在Brsud Tabanan的急性心肌梗死患者入院和良好死亡率患者的淋巴细胞比率之间的联系
5. The role of mucosal resident virus-specific CD8+ T lymphocytes in acute SIV infection and the development of HIV vaccines. [D] . Reynolds, Matthew Robert. 2006

机译：黏膜常驻病毒特异性CD8 + T淋巴细胞在急性SIV感染和HIV疫苗开发中的作用。
6. Targeting miR-23a in CD8+ cytotoxic T lymphocytes prevents tumor-dependent immunosuppression [O] . Regina Lin, Ling Chen, Gang Chen, 2014

机译：在CD8 +细胞毒性T淋巴细胞中靶向miR-23a可防止肿瘤依赖性免疫抑制
7. Cytotoxic function of CD8+ T lymphocytes isolated from patients with acute severe cerebral infarction: an assessment of stroke-induced immunosuppression [O] . Gang Li, Xin Wang, Li-hong Huang, 2013

机译：急性重症脑梗死患者CD8 + T淋巴细胞的细胞毒性功能：中风诱导的免疫抑制评估

Cytotoxic function of CD8+ T lymphocytes isolated from patients with acute severe cerebral infarction: an assessment of stroke-induced immunosuppression

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