class="head no_bottom_margin" id="__sec2title">BackgroundNegative Pressure Wound Therapy (NPWT) is primarily used for very complex chronic wounds. The surgical treatment of the diabetic wounds with loss of soft tissue usually consists of closure using split-thickness skin grafts or transposition flaps. However, the first step consists of standard wound care with moist gauze dressing with the aim to prepare the wound bed for final closure. Clinical and experimental studies reported that negative pressure increases local blood flow and decreases bacterial colonization. Localized negative pressure removes fluids from the wound and promotes the granulation tissue, which is required for wound closure.
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机译：class =“ head no_bottom_margin” id =“ __ sec2title”>背景负压伤口治疗（NPWT）主要用于非常复杂的慢性伤口。糖尿病性伤口伴软组织丢失的外科治疗通常包括使用裂开厚度的皮肤移植物或移位皮瓣进行封闭。然而，第一步是用湿纱布敷料进行标准伤口护理，目的是为最终封闭做好伤口床的准备。临床和实验研究报告称，负压可增加局部血流量并减少细菌定植。局部负压可从伤口中清除液体并促进肉芽组织，这是伤口闭合所必需的。
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