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Novel drug-regulated transcriptional networks in brain reveal pharmacological properties of psychotropic drugs

机译：脑中新型药物调控的转录网络揭示了精神药物的药理特性

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摘要

BackgroundDespite their widespread use, the biological mechanisms underlying the efficacy of psychotropic drugs are still incompletely known; improved understanding of these is essential for development of novel more effective drugs and rational design of therapy. Given the large number of psychotropic drugs available and their differential pharmacological effects, it would be important to establish specific predictors of response to various classes of drugs.

机译：背景技术尽管广泛使用，但精神药物疗效的生物学机制仍不完全清楚。更好地理解这些对于开发更有效的新型药物和合理设计治疗至关重要。鉴于可用的精神药物数量众多，并且它们具有不同的药理作用，因此重要的是建立对各种药物反应的具体预测因子。

著录项

期刊名称 BMC Genomics
作者
Michal Korostynski; Marcin Piechota; Jaroslaw Dzbek; Wiktor Mlynarski; Klaudia Szklarczyk; Barbara Ziolkowska; Ryszard Przewlocki;
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作者单位

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年(卷),期 2013(14),-1
年度 2013
页码 606
总页数 14
原文格式 PDF
正文语种
中图分类遗传学;应用微生物学;
关键词
Gene expression patterns Psychotropic drugs Striatum Molecular classification;

机译：基因表达方式;精神药物;纹状体;分子分类;

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专利

1. Novel drug-regulated transcriptional networks in brain reveal pharmacological properties of psychotropic drugs [J] . Michal Korostynski, Marcin Piechota, Jaroslaw Dzbek, BMC Genomics . 2013,第1期

机译：脑中新型药物调节的转录网络揭示了精神药物的药理特性
2. Comparing structural and transcriptional drug networks reveals signatures of drug activity and toxicity in transcriptional responses [J] . Francesco Sirci, Francesco Napolitano, Sandra Pisonero-Vaquero, NPJ systems biology and applications. . 2017,第1期

机译：结构和转录药物网络的比较揭示了转录反应中药物活性和毒性的特征
3. Decoding the transcriptional programs activated by psychotropic drugs in the brain [J] . Zygmunt Magdalena, Piechota Marcin, Rodriguez Parkitna Jan, Genes, brain, and behavior . 2019,第4期

机译：解码大脑中精神药物激活的转录程序
4. Neural network research based on drug properties: the effect of vasomotor on brain signals [C] . Miao Zhang, Xuan Zhao IEEE Joint International Information Technology and Artificial Intelligence Conference . 2020

机译：基于药物性质的神经网络研究：血管运动对脑信号的影响
5. Creatine Phosphokinase Levels in Patients with Psychiatric disorder: Comparative Study among Drug -naive / Drug -free Patients, Patients on Psychotropic drugs and Normal population. [D] . Dattatraya, Chavan Vilas. 2015

机译：精神病患者的肌酸磷酸激酶水平：未使用药物/未使用药物的患者，使用精神药物的患者和正常人群之间的比较研究。
6. Comparing structural and transcriptional drug networks reveals signatures of drug activity and toxicity in transcriptional responses [O] . Francesco Sirci, Francesco Napolitano, Sandra Pisonero-Vaquero, 2017

机译：结构和转录药物网络的比较揭示了转录反应中药物活性和毒性的特征
7. Novel drug-regulated transcriptional networks in brain reveal pharmacological properties of psychotropic drugs [O] . Michal Korostynski, Marcin Piechota, Jaroslaw Dzbek, 2013

机译：脑中新型药物调控的转录网络揭示了精神药物的药理特性

Novel drug-regulated transcriptional networks in brain reveal pharmacological properties of psychotropic drugs

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