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Comparative genome analysis identifies two large deletions in the genome of highly-passaged attenuated Streptococcus agalactiae strain YM001 compared to the parental pathogenic strain HN016

机译：比较基因组分析确定了高度传代的减毒无乳链球菌菌株YM001与亲本病原菌株HN016相比在基因组中的两个大缺失

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BackgroundStreptococcus agalactiae (S. agalactiae), also known as group B Streptococcus (GBS), is an important pathogen for neonatal pneumonia, meningitis, bovine mastitis, and fish meningoencephalitis. The global outbreaks of Streptococcus disease in tilapia cause huge economic losses and threaten human food hygiene safety as well. To investigate the mechanism of S. agalactiae pathogenesis in tilapia and develop attenuated S. agalactiae vaccine, this study sequenced and comparatively analyzed the whole genomes of virulent wild-type S. agalactiae strain HN016 and its highly-passaged attenuated strain YM001 derived from tilapia.

机译：背景无乳链球菌（S. agalactiae），也称为B组链球菌（GBS），是新生儿肺炎，脑膜炎，牛乳腺炎和鱼类脑膜脑炎的重要病原体。罗非鱼链球菌病的全球爆发造成巨大的经济损失，也威胁着人类食品卫生安全。为了研究罗非鱼无乳链球菌致病机理并开发减毒无乳链球菌疫苗，本研究对有毒野生型无乳链球菌无核菌株HN016及其衍生自罗非鱼的高传代减毒菌株YM001的全基因组进行了测序和比较。

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期刊名称 BMC Genomics
作者
Rui Wang; Liping Li; Yan Huang; Fuguang Luo; Wanwen Liang; Xi Gan; Ting Huang; Aiying Lei; Ming Chen; Lianfu Chen;
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作者单位

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年(卷),期 2015(16),-1
年度 2015
页码 897
总页数 10
原文格式 PDF
正文语种
中图分类遗传学;应用微生物学;
关键词
Streptococcus agalactiae Genetic variation Virulence attenuation Sequence analysis Virulence factors;

机译：无乳链球菌;遗传变异;毒力衰减;序列分析;毒力因子;

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专利

1. Comparative genome analysis identifies two large deletions in the genome of highly-passaged attenuated Streptococcus agalactiae strain YM001 compared to the parental pathogenic strain HN016 [J] . Rui Wang, Liping Li, Yan Huang, BMC Genomics . 2015,第1期

机译：比较基因组分析确定了高度传代的减毒无乳链球菌菌株YM001与亲本病原菌株HN016相比在基因组中的两个大缺失
2. Comparative genome analysis identifies two large deletions in the genome of highly-passaged attenuated Streptococcus agalactiae strain YM001 compared to the parental pathogenic strain HN016 [J] . Rui Wang, Liping Li, Yan Huang, BMC Genomics . 2015,第1期

机译：比较基因组分析确定了高度传代的减毒无乳链球菌菌株YM001与亲本病原菌株HN016相比在基因组中的两个大缺失
3. Pathogenic and antimicrobial resistance genes in Streptococcus oralis strains revealed by comparative genome analysis [J] . Jiannan Zhou, Tianyong Sun, Wenyan Kang, Genomics . 2020,第5期

机译：对比较基因组分析显示的链球菌菌株中的病原和抗微生物抗性基因
4. Insights into Streptococcus suis genome: Map-based comparative genomic analysis [C] . Paulraj K. Lawrence American Association of Swine Veterinarians Annual Meeting . 2015

机译：探讨链球菌的见解：基于地图的比较基因组分析
5. Comparing the genome expression profiles of Verrucomicrobium sp. strain TAV2 cells grown under two different oxygen concentrations. [D] . Willis, Austin. 2010

机译：比较疣疣菌的基因组表达谱。株TAV2细胞在两种不同的氧气浓度下生长。
6. Draft Genome Sequence of a Nonhemolytic Fish-Pathogenic Streptococcus agalactiae Strain [O] . Christian M. J. Delannoy, Ruth N. Zadoks, Frederick A. Lainson, 2012

机译：非溶血性鱼类致病性无乳链球菌菌株的基因组序列草案
7. Comparative genome analysis identifies two large deletions in the genome of highly-passaged attenuated strain YM001 compared to the parental pathogenic strain HN016 [O] . 2015

机译：比较基因组分析确定了高度传代的减毒菌株YM001与亲本病原菌株HN016相比基因组中的两个大缺失

Comparative genome analysis identifies two large deletions in the genome of highly-passaged attenuated Streptococcus agalactiae strain YM001 compared to the parental pathogenic strain HN016

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