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Transcriptome analysis of the two unrelated fungal β-lactam producers Acremonium chrysogenum and Penicillium chrysogenum: Velvet-regulated genes are major targets during conventional strain improvement programs

机译：两种无关的真菌β-内酰胺生产者Acremonium chrysogenum和Penicillium chrysogenum的转录组分析：常规菌株改良计划中天鹅绒调节的基因是主要目标

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BackgroundCephalosporins and penicillins are the most frequently used β-lactam antibiotics for the treatment of human infections worldwide. The main industrial producers of these antibiotics are Acremonium chrysogenum and Penicillium chrysogenum, two taxonomically unrelated fungi. Both were subjects of long-term strain development programs to reach economically relevant antibiotic titers. It is so far unknown, whether equivalent changes in gene expression lead to elevated antibiotic titers in production strains.

机译：背景头孢菌素和青霉素是世界范围内用于治疗人类感染的最常用的β-内酰胺抗生素。这些抗生素的主要工业生产者是两种动物分类学上无关的真菌：黄曲霉和黄青霉。两者都是长期菌株开发计划的主题，目的是达到经济上相关的抗生素效价。迄今为止还不清楚基因表达的等效变化是否会导致生产菌株中抗生素滴度升高。

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期刊名称 BMC Genomics
作者
Dominik Terfehr; Tim A. Dahlmann; Ulrich Kück;
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作者单位

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年(卷),期 2017(18),-1
年度 2017
页码 272
总页数 19
原文格式 PDF
正文语种
中图分类遗传学;应用微生物学;
关键词
Penicillin Cephalosporin Gene expression Acremonium chrysogenum Penicillium chrysogenum Velvet RNA-seq Strain improvement Secondary metabolism Amino acid metabolism;

机译：青霉素;头孢菌素;基因表达;产黄顶孢菌;产黄青霉;天鹅绒;RNA-seq;菌株改良;二级代谢;氨基酸代谢;

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1. Transcriptome analysis of the two unrelated fungal β-lactam producers Acremonium chrysogenum and Penicillium chrysogenum : Velvet-regulated genes are major targets during conventional strain improvement programs [J] . Dominik Terfehr, Tim A. Dahlmann, Ulrich Kück BMC Genomics . 2017,第1期

机译：两种无关的真菌β-内酰胺生产者Acremonium chrysogenum和Penicillium chrysogenum的转录组分析：在常规菌株改良计划中，天鹅绒调节的基因是主要目标
2. RNA-silencing in Penicillium chrysogenum and Acremonium chrysogenum: Validation studies using beta-lactam genes expression. [J] . Ullan RV, Godio RP, Teijeira F, Journal of Microbiological Methods . 2008,第2期

机译：产黄青霉和产黄顶孢中的RNA沉默：使用β-内酰胺基因表达的验证研究。
3. Genomic mutational analysis of the impact of the classical strain improvement program on β–lactam producing Penicillium chrysogenum [J] . Oleksandr V. Salo, Marco Ries, Marnix H. Medema, BMC Genomics . 2015,第1期

机译：基因组突变分析古典菌株改善计划对β-内酰胺生产的甲基霉菌植物
4. CONSTRUCTION OF A SECONDARY METABOLITE DEFICIENT PENICILLIUM CHRYSOGENUM STRAIN AS A GENERIC PRODUCTION HOST FOR SECONDARY METABOLITES [C] . Fabiola Polli, Annarita Viaggiano, Oleksander Salo, Enzyme engineering XXIV . 2017

机译：次生代谢缺陷型青霉青霉菌菌株的构建，作为次生代谢产物的一般生产宿主
5. ISOLATION AND CHARACTERIZATION OF GENES FROM BETA-LACTAM ANTIBIOTIC PRODUCING ORGANISMS (PENICILLIUM CHRYSOGENUM, RIBOSOMAL-RNA, CEPHALOSPORIUM ACREMONIUM, ISOPENICILLIN N SYNTHETASE). [D] . CARR, LUCINDA GAYLE. 1986

机译：从β-内酰胺类抗生素生产基因（青霉菌，核糖体RNA，头孢杆菌，异戊二烯N合成酶）中分离和鉴定基因。
6. Genomic mutational analysis of the impact of the classical strain improvement program on β–lactam producing Penicillium chrysogenum [O] . Oleksandr V. Salo, Marco Ries, Marnix H. Medema, 2015

机译：基因组突变分析经典菌株改良程序对产β-内酰胺的产黄青霉的影响
7. Transcriptome analysis of the two unrelated fungal β-lactam producers Acremonium chrysogenum and Penicillium chrysogenum: Velvet-regulated genes are major targets during conventional strain improvement programs [O] . Dominik Terfehr, Tim A. Dahlmann, Ulrich Kück 2017

机译：两种不相关的真菌β-内酰胺生产者Acremonium chrysogenum和Penicillium chrysogenum的转录组分析：在常规菌株改良计划中，天鹅绒调节的基因是主要目标

Transcriptome analysis of the two unrelated fungal β-lactam producers Acremonium chrysogenum and Penicillium chrysogenum: Velvet-regulated genes are major targets during conventional strain improvement programs

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