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Transcriptome analysis reveals differential immune related genes expression in bovine viral diarrhea virus-2 infected goat peripheral blood mononuclear cells (PBMCs)

机译:转录组分析揭示了牛病毒性腹泻病毒2感染的山羊外周血单核细胞(PBMC)中差异免疫相关基因的表达

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摘要

BackgroundBovine viral diarrhea virus (BVDV) is an economically important viral pathogen of domestic and wild ruminants. Apart from cattle, small ruminants (goats and sheep) are also the susceptible hosts for BVDV. BVDV infection could interfere both of the innate and adaptive immunity of the host, while the genes and mechanisms responsible for these effects have not yet been fully understood. Peripheral blood mononuclear cells (PBMCs) play a pivotal role in the immune responses to viral infection, and these cells were the target of BVDV infection. In the present study, the transcriptome of goat peripheral blood mononuclear cells (PBMCs) infected with BVDV-2 was explored by using RNA-Seq technology.
机译:背景技术牛病毒性腹泻病毒(BVDV)是家养和野生反刍动物的一种重要的经济病毒病原体。除牛以外,小反刍动物(山羊和绵羊)也是BVDV的易感宿主。 BVDV感染可能会干扰宿主的先天免疫和适应性免疫,而导致这些作用的基因和机制尚未完全被了解。外周血单个核细胞(PBMC)在对病毒感染的免疫反应中起关键作用,这些细胞是BVDV感染的靶标。在本研究中,使用RNA-Seq技术探索了感染BVDV-2的山羊外周血单个核细胞(PBMC)的转录组。

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